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Use of clean technology in the national production of active principles with pharmacological activity

Grant number: 99/11665-4
Support type:Research Grants - Innovative Research in Small Business - PIPE
Duration: November 01, 2000 - January 31, 2004
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Moacir de Mancilha
Grantee:Moacir de Mancilha
Company:Synthon Especialidades Químicas Ltda
City: Sorocaba


The treatment for pulmonary tuberculosis consists of the association of medication, good nutrition and rest. The first drugs used were streptomycin, isoniazid and para-aminosalicylic acid, all capable of eradicating the tuberculosis bacillus from the human organism. Other effective drugs are etambutol, rifampicin, thiacetazone and pirazinamid. Although the infection is halted quickly, the complete cure requires several months of treatment. Thus, it is of strategic importance that Brazil becomes self-sufficient in these medicines. The production of pirazinamid was discontinued in the country and, in the last 8 years around 79 tons of technical pirazinamid were imported, which signified a foreign exchange cost of US$ 3,333,678. The objectives of this project are: 1) the development of clean methodologies for the production of drugs for the treatment of tuberculosis (pirazinamid); 2) subsequent implementation on an industrial scale. The methodologies to be developed consist of: 3) studying the oxidization of quinoxalin 6 through the use of ozone with catalytic quantities of manganese dioxide, and 4) studying the synthesis of pirazinamid from 2,3-diamino-propionic acid 9. (AU)

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