JAK2 and IRS-1 as intra-cell messengers in the connection between insulin signaling paths, AII and GH: physiological and physiopathological implications

• Grant number: 96/12374-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 1997
• End date: February 28, 2002
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Mario Jose Abdalla Saad
• Grantee: Mario Jose Abdalla Saad
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant(s): 01/04855-3 - A population-based sample of brazilian newborns., AR.EXT

Abstract

This project seeks to investigate the physiological and physiopathological implications of "cross talk” between signal transmission paths for three hormones: insulin AII and GH. The cytoplasmatic proteins IRS-1 and JAK-2 are essences in these connections and we intend to investigate interactions between these proteins in animal models and cell culture, after infusion of these hormones, simulating physiopathological situations with important clinical implications. (AU)