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Immunological evaluation in uveitis: study of the immune response and of inflammation in an immunoprivileged organ


We intend to establish a model of autoimmune uveitis in non-isogenic mice to study the polygenic control of the immune response in autoimmune illnesses. We will study the effect of the absence of IL-4 and IFN-g in the course of experimental chronic autoimmune uveitis (EAU). The importance of inflammatory cytokines in vitreous and aqueous humor will be studied in the experimental model of ocular inflation. We will also study aspects of immunopathogenesis and immunogenetics of coreoretinitis caused by the Toxoplasma gondii, with emphasis on the immunological differentiation. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
A.L. VALLOCHI; J.H. YAMAMOTO; D. SCHLESINGER; M.A.C. MACHADO; C. SILVEIRA; M.C. MARTINS; R. BELFORT JR.; J. KALIL; L.V. RIZZO. Lack of evidence for superantigen activity of Toxoplasma gondii towards human T cells. Brazilian Journal of Medical and Biological Research, v. 34, n. 8, p. 1023-1031, . (98/11205-0)

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