Immunological evaluation in uveitis: study of the immune response and of inflammation in an immunoprivileged organ

• Grant number: 98/11205-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: January 01, 1999 - January 31, 2005
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Luiz Vicente Rizzo
• Grantee: Luiz Vicente Rizzo
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Osvaldo Augusto Brazil Esteves Sant'Anna ; Rubens Belfort Mattos Junior
• Associated scholarship(s): 04/11614-0 - Influence of inflammatory response in experimental syngeneic transplantation, BP.MS; 04/04981-7 - Immunological evaluation in uveitis: study of the immune response and inflammation in an immune-privileged organ, BP.TT

Abstract

We intend to establish a model of autoimmune uveitis in non-isogenic mice to study the polygenic control of the immune response in autoimmune illnesses. We will study the effect of the absence of IL-4 and IFN-g in the course of experimental chronic autoimmune uveitis (EAU). The importance of inflammatory cytokines in vitreous and aqueous humor will be studied in the experimental model of ocular inflation. We will also study aspects of immunopathogenesis and immunogenetics of coreoretinitis caused by the Toxoplasma gondii, with emphasis on the immunological differentiation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

A.L. VALLOCHI; J.H. YAMAMOTO; D. SCHLESINGER; M.A.C. MACHADO; C. SILVEIRA; M.C. MARTINS; R. BELFORT JR.; J. KALIL; L.V. RIZZO. Lack of evidence for superantigen activity of Toxoplasma gondii towards human T cells. Brazilian Journal of Medical and Biological Research, v. 34, n. 8, p. 1023-1031, 2001-08-00. (98/11205-0)