| Grant number: | 98/00410-2 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | November 01, 1998 |
| End date: | June 30, 2003 |
| Field of knowledge: | Biological Sciences - Biochemistry - Molecular Biology |
| Principal Investigator: | Célia Regina da Silva Garcia |
| Grantee: | Célia Regina da Silva Garcia |
| Host Institution: | Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant(s): | 99/04765-2 - Anton R. Dluzewski | King's College School of Medicine and Dentistry - Inglaterra, AV.EXT |
| Associated scholarship(s): | 01/01755-8 - Studying chloroquine mechanisms of action in Plasmodium sp. using microphysiometer, BP.IC |
Abstract
The nature of the mechanisms underlying Ca2+ homeostasis in malaria parasites has puzzled investigators for almost two decades. Ca2+ is a ubiquitous messenger in eukaryotic cell signaling and its binding to proteins leads to changes in their activity and thus in the control of many cellular events. Our laboratory has been working with human malaria parasite, Plasmodium falciparum and the rodent parasite, Plasmodium chabaudi. The lab is set up for the study of the basic mechanisms controlling Ca2+ handling in malaria parasites which is important for understanding the physiology of these cells, but also to obtain clues as to potential role of this second messenger in signal transduction and host cell attack. We have recently extended our study of signaling transduction aspects to lizard parasites. Lizard Plasmodium occurs in Amazonia region and unlike the other Plasmodium species, it is not lethal although accounts for almost 50% of the Plasmodium species. (AU)
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