Alternative modes of activation and deactivation of neutrophils and monocytic cells

• Grant number: 03/10077-9
• Support Opportunities: PRONEX Research - Thematic Grants
• Start date: July 01, 2004
• End date: December 31, 2007
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Agreement: CNPq - Pronex
• Principal Investigator: Ana Campa
• Grantee: Ana Campa
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The resolution of the inflammatory process depends on an effective balance between activation and deactivation of inflammatory cells. The activation of these cells is regulated by cytokines, hormones and bioactive lipids. Our research group's previous studies identified two additional possibilities to control the activation of inflammatory cells: 1) the catalytic action of peroxidase (MPO) on endogenous compounds, particularly melatonin, and 2) the participation of the acute phase protein serum amyloid A (SAA) in the activation of neutrophils and monocytic. Our aim now is to perform in-depth studies of the biological roles of SAA and the melatonin oxidation in the inflammation and progression of chronic diseases, to identify new modulators, and, to define the interrelationship between the NAOPH oxidase system and the enzymes, MPO and indoleamine 2, 3 dioxygenase in the cross-talk of cells of the immune system. (AU)