Interactions betwee membranes, biomolecules and surfaces

• Grant number: 98/11480-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 1999
• End date: October 31, 2005
• Field of knowledge: Biological Sciences - Biophysics
• Principal Investigator: Ana Maria Carmona-Ribeiro
• Grantee: Ana Maria Carmona-Ribeiro
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 04/10343-3 - Dioctadecyldimethylammonium bromide (dna) and a recombinant, fusion protein from mycobacterium tuberculosis available from the tuberculosis research unit at statens serum institu in copenhagen..., BP.PD

Abstract

Physic-chemical factors that determine interactions between bilayer vesicles, biomolecules and surfaces are poorly understood. Research will be focused on interactions: 1) synthetic bitayer vesicles and oppositely charged polystyrene microspheres or polyrnerie films; 2) antimicrobial cationic vesicles and cell surfaces of clinically important microorganisms such as bacteria, fungi and mycoplasma; 3) phospholipid or synthetic vesicles and mineral surfaces; 4) cationic vesicles and oppositely charged biomolecules such as serum proteins or DNA. The results may be of importance for strategic applied areas (design of vaccines, biosensors and immunological kits, water treatment and gene therapy). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PUEYO, MANUEL TROYANO; BLOCH, JR., CARLOS; CARMONA-RIBEIRO, ANA MARIA; DI MASCIO, PAOLO. Lipopeptides Produced by a Soil Bacillus Megaterium Strain. MICROBIAL ECOLOGY, v. 57, n. 2, p. 367-378, FEB 2009. (98/11480-1)

Filed patent(s) as a result of this research project