Nucleus for research into pre-clinical neuroimage (center for experimental neuroimage

• Grant number: 06/61333-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2007
• End date: March 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Luiz Augusto Franco de Andrade
• Grantee: Luiz Augusto Franco de Andrade
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

The present proposal aims to establish a center for pre-clinical imaging to support advanced research in neuro-imaging and experimental neurology. Three research projects make up this thematic project. The first is a study of molecular neuro-imaging in Parkinson's disease (PD), focused on preclinical models of dopaminergic neuro-adaptation in the early and late forms of the disease. The second is aimed at the in vivo finding of hippocampal dopaminergic projections in mice subjected to the experimental model of epilepsy induced by pilocarpine. The third is a study of the functional genomic of PD and aims to clarify the molecular mechanism of the disease, based on analyses of differential genetic expression in four specific encephalic areas. Among the principal results expected are: 1) implantation of a nucleus of preclinical image with use of high resolution SPECT; and 2) important advances in knowledge about epilepsy and PD, focusing on the physiopathology and the molecular mechanisms involved. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS REIS, MARILIA ALVES; MEJIA, JORGE; BATISTA, ILZA ROSA; FELISA FIGOLS DE BARBOZA, MARYCEL ROSA; NOGUEIRA, SOLANGE AMORIM; WAGNER, JAIRO; CABRAL, FRANCISCO ROMERO; VICTORIO MENDONCA DAVOGLIO, PETRICK MARCELLUS; ABILIO, VANESSA COSTHEK; FU, GENG; et al. SPEM: A state-of-the-art instrument for high resolution molecular imaging of small animal organs. Einstein (São Paulo), v. 10, n. 2, p. 7-pg., 2012-04-01. (08/08902-5, 06/61333-3)