Toxins of importance in veterinary medicine: studies of the immunotoxicity and teratogenicity in rodents and caprines

• Grant number: 06/60397-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: October 01, 2007
• End date: November 30, 2011
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Silvana Lima Gorniak
• Grantee: Silvana Lima Gorniak
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Helenice de Souza Spinosa ; Maria Lucia Zaidan Dagli ; Mitsue Haraguchi
• Associated research grant(s): 08/54550-3 - James Pfister | Agricultural Research Service - Estados Unidos, AV.EXT

Abstract

One of the main causes of losses in Brazilian cattle farming is due to poisoning from toxins, present in plants or those produced by fungi, given that the economic losses caused by this type of poisoning are related, basically, to the frequent and prolonged exposure of the animals to these substances, which can produce effects, such as: fall in productivity and weight gain, alterations in the immune system, such as, for example, immunosuppression, which could favor the development of infections or parasitical diseases; and also to be considered are the reproductive alterations caused by these toxins, particularly those teratogenetic effects. There, the present thematic project aims to study the immunotoxic and teratogenetic effects of some of the most important toxins of significance, both for animal rearing, and for public health. The carrying out of this thematic project will permit the implementation and development of protocols of immunotoxicity and teratogeneticity in our laboratory. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HUEZA, I. M.; TANABE, V. K.; BENASSI, J. C.; RASPANTINI, L. E. R.; GORNIAK, S. L.; RIETCORREA, F; PFISTER, J; SCHILD, AL; WIERENGA, T. Zearalenone: An Estrogenic Mycotoxin with Immunotoxic Effects. POISONING BY PLANTS, MYCOTOXINS, AND RELATED TOXINS, v. N/A, p. 5-pg., 2011-01-01. (06/60397-8)

HUEZA, ISIS M.; BENASSI, JULIA C.; RASPANTINI, PAULO C. F.; RASPANTINI, LEONILA E. R.; SA, LILIAN R. M.; GORNIAK, SILVANA L.; HARAGUCHI, MITSUE. Low doses of monocrotaline in rats cause diminished bone marrow cellularity and compromised nitric oxide production by peritoneal macrophages. JOURNAL OF IMMUNOTOXICOLOGY, v. 6, n. 1, p. 11-18, 2009. (06/60397-8)

ELIAS, F.; HUEZA, I. M.; HARAGUCHI, M.; GORNIAK, S. L.; RIETCORREA, F; PFISTER, J; SCHILD, AL; WIERENGA, T. Evaluation of Immunotoxic Properties of Senecio brasiliensis: Study of Toxicity in Rats. POISONING BY PLANTS, MYCOTOXINS, AND RELATED TOXINS, v. N/A, p. 4-pg., 2011-01-01. (06/60397-8)

BENASSI, J. C.; HARAGUCHI, M.; GORNIAK, S. L.; HUEZA, I. M.; RIETCORREA, F; PFISTER, J; SCHILD, AL; WIERENGA, T. Comparative Study of Monocrotaline Toxicity on Peritoneal Macrophage Activity When Dosed for 14 or 28 Days. POISONING BY PLANTS, MYCOTOXINS, AND RELATED TOXINS, v. N/A, p. 5-pg., 2011-01-01. (06/60397-8)