Ultrasonometric evaluation of bone healing and cortical bone density

• Grant number: 07/56422-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2008
• End date: March 31, 2012
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Claudio Henrique Barbieri
• Grantee: Claudio Henrique Barbieri
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Carlos Alberto Pela ; Nilton Mazzer

Abstract

Ultrasonometry is a non-invasive non-ionizing method to evaluate bane mass which is still under investigation concerning diseases such as osteoporosis. Despite the existence of works on the clinical application of the method, its use to evaluate the healing process of fractures is still considered experimental, since there is no clear application protocol, nor quantified parameters with time. An experimental in vitro study carried out among us showed that the ultrasound propagation velocity increases with the healing of osteotomies of the tibiae of sheep, steadily approaching the values measured in the normal tibiae, thus demonstrating a great potential for clinical application, perhaps not as replacement of the conventional methods (radiographs, computed tomography, magnetic resonance imaging), but as an additional method, with the advantage of being much cheaper and virtually devoid of any harmful effect. Furthermore, it can be applied with low cost portable equipment, without the need of specialized personnel. According to the proposed project, seven separate investigations will be conducted on the use of ultrasonometry of bone healing and cortical bane density using different experimental models. A clinical trial will also be undertaken to study the healing of forearm fractures in humans. Additionally, the technology of the equipment, so far only available as a laboratory assembly, will be improved so as to develop a commercial version with the assistance of a specialized manufacturer. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBIERI, GIULIANO; MAZZER, NILTON; RIBEIRO, EDUARDO ALVAREZ; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE; BARBIERI, CLAUDIO HENRIQUE. A Comparative Analysis between Ultrasonometry and Computer-Aided Tomography to Evaluate Bone Healing. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 30, n. 7, p. 1076-1082, JUL 2012. (07/56422-0)

BARBIERI, GIULIANO; BARBIERI, CLAUDIO HENRIQUE; MAZZER, NILTON; PELA, CARLOS ALBERTO. Ultrasound Propagation Velocity and Broadband Attenuation Can Help Evaluate the Healing Process of an Experimental Fracture. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 29, n. 3, p. 444-451, MAR 2011. (07/56422-0)

MANDARANO-FILHO, LUIZ GARCIA; BEZUTI, MARCIO TAKEY; BARBIERI, CLAUDIO HENRIQUE. In vivo standardization of bone ultrasonometry of the clavicle. Clinics, v. 71, n. 3, p. 140-144, 2016. (07/56422-0)

BEZUTI, MARCIO TAKEY; MANDARANO-FILHO, LUIZ GARCIA; BARBIERI, GIULIANO; MAZZER, NILTON; BARBIERI, CLAUDIO HENRIQUE. INFLUENCE OF THE OSTEOSYNTHESIS PLATE ON ULTRASOUND PROPAGATION IN THE BONE. Acta Ortopédica Brasileira, v. 22, n. 5, p. 269-274, SEP-OCT 2014. (07/56422-0)

MÁRCIO TAKEY BEZUTI; LUIZ GARCIA MANDARANO FILHO; GIULIANO BARBIERI; NILTON MAZZER; CLÁUDIO HENRIQUE BARBIERI. Avaliação ultrassonométrica da osteossíntese de compressão axial: estudo experimental. Acta Ortopédica Brasileira, v. 21, n. 1, p. 46-51, 2013-02-00. (07/56422-0)

BARBIERI, GIULIANO; BARBIERI, CLAUDIO HENRIQUE. A comparative in vivo ultrasonometric evaluation of normal and delayed fracture healing in sheep tibiae. Clinics, v. 69, n. 9, p. 634-640, 2014. (07/56422-0)

BEZUTI, MARCIO TAKEY; MANDARANO FILHO, LUIZ GARCIA; BARBIERI, GIULIANO; MAZZER, NILTON; BARBIERI, CLAUDIO HENRIQUE. ULTRASONOMETRY EVALUATION OF AXIAL COMPRESSION OSTEOSINTHESIS. AN EXPERIMENTAL STUDY. Acta Ortopédica Brasileira, v. 21, n. 1, p. 46-51, 2013. (07/56422-0)