Ventricular ablation: a new method to induce uniforme and low mortality myocardial infarction in the rat

• Grant number: 06/01118-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2006
• End date: August 31, 2007
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Paulo Jose Ferreira Tucci
• Grantee: Paulo Jose Ferreira Tucci
• Host Institution: Departamento de Fisiologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Myocardial infarction (MI) induced in the rat is the most utilized experimental model for myocardial remodeling and heart failure studies. High immediate mortality and MI size high variability are two disadvantages of this method. We aim to standardize the MI induction in the rat by radio-frequency ablation. In preliminary studies we showed that myocardial ablation allows MI very homogeneous in size. Immediate mortality seems to be trivial. In order to describe the pattern of MI induced by myocardial ablation we propose to evaluate the evolution of electrocardiogram, Doppler echocardiogram, hemodynamic and hystological sections in four groups of infarcted rats: a) immediately after myocardial ablation; b) one weeks after MI; c) four weeks after MI and d) six weeks after MI. (AU)