Development of theranostic systems based on ZnO and lipid nanocapsules
| Grant number: | 06/01277-2 |
| Support type: | Regular Research Grants |
| Duration: | July 01, 2006 - October 31, 2009 |
| Field of knowledge: | Physical Sciences and Mathematics - Physics |
| Principal Investigator: | Viviane Pilla |
| Grantee: | Viviane Pilla |
| Home Institution: | Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Camilo Castelo Branco (UNICASTELO). São Paulo , SP, Brazil |
Abstract
The project will be developed at the laboratory of the Group of Lasers of high power applied to BioEngineering - IP&D/UniVap. The present proposal is gone back to the study of both optical and thermal properties of biocompatible new nanomaterials, seeking a subsequent application in materials of biomedical interest, as: biological tissues and applications in dentistry. As it is a theme of scientific and technological importance, once this is an area of recent research, the study of the quantum dots is quite promising and with great potentiality for future applications. The research line of this work will be of the experimental optical characterization. This project will focalize in the study of both linear and nonlinear optical properties of several colloidal functionalized QD (diluted in water) approved for biological applications. The Group of Lasers of high power applied to BioEngineering of the IP&D/UniVap has been working actively with applied spectroscopy to biomedical materials, for instance: ablation of biological skins and other studies in the area of health sciences and of biological interest. This knowledge will be of fundamental importance, to make possible future applications of the semiconductor nanocrystals, whose plan of current work, intends to study them in level of basic characterization of the linear and nonlinear spectroscopy. Initially, we will accomplish a characterization of the quantum dots through optical absorption in the Vis-UV. These characterizations seek to verify the possible alterations in the optical properties of the nanoparticles solutions, in function of the concentration, pH and exposure to the laser. As second stage of our work, we will implement the technique of Thermal Lens (TL), seeking the characterization of parameters, as: thermal diffusivity, thermal conductivity, variation of the refraction index with the variation of the temperature and radiative quantum efficiency. These studies will be accomplished in function of the wavelength of the both probe and excitation beams, pH, concentration and size of QD. The quantum dots that will be studied are: Type 1 and Type 2. Where, Type 1 (or Type 2) presents synthetic coating (or natural ligand surface), in the presence of functionalized group (either amine or carboxyl terminal group) or no functional group. Also, variations of QD of the Type 2 will be analyzed, denominated as: QD T2-MP and QD T2-Biotin. QD T2-MP presents nucleus containing three semiconductors, molecular coating and covering with natural lipids. QD T2-Biotin contains biotin molecules. Fluorescence measures will be used as coadjutant for understanding the processes studied above with the techniques mentioned. In a general way, the result that we intend to obtain in the end of the development of the project is an evaluation (of the point of view of the linear and nonlinear optical) the potentiality of the commercials colloidal solutions (QD) biocompatible for applications in Biophotonic. In this way, we will use the technique of Thermal Lens, which will be implemented in the IP&D/UniVap. (AU)