Experimental study in rabbits of treatment of model of Rhinosinusitis with aerosolized furoate of mometasone associated to ampicillin

• Grant number: 06/04135-4
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2007
• End date: June 30, 2008
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Luc Louis Maurice Weckx
• Grantee: Luc Louis Maurice Weckx
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The prevalence of infecto-inflammatory diseases of the airways is extremely high in the general population. The treatment of the rhinosinusites can be done in many ways. Besides, there are a variety of clinical patterns and predisposing factors, as well as associated situations that hinder the understanding of the pathology. The treatment with oral antibiotics for community infectious agents and its association with corticosteroids is one of the most effective treatments for this affection. A possible way of presenting drugs to the airway has been the aerosol form. The possibility to present the more frequently prescribed drugs under this form could facilitate the treatment of the bacterial rhinosinusitis. Therefore, we see the need to study, in appropriate experimental models, the use of the association of antibiotics and corticosteroid under the aerosol form. Objective: to evaluate the effectiveness of the use of the association of mometasona's furoato and ampicilina under aerosol form in experimental model of bacterial rhinosinusitis. Material and Method: 60 rabbits will be accompanied up to 30 days. The animals will be submitted to proceedings need to achieve an experimental model of bacterial rhinosinusitis in agreement with the technique established previously by the authors that consists of blockade of the nasal cavity with sponge associated with the instilation of toxoid of streptococcus and staphilococcus and blood in the maxillary antrum. Once reached the model, a group will be treated with the drug association and other group will receive the vehicle without drug. The animals will be followed for periods of 5 days, 15 days and 30 days. The antri maxillaries will be appraised histologically and with culture of its secretion, and the results compared with the control and among the intervention groups. All the animals will have samples of blood collected in the 1st. day, 5th. day and day of the euthanasia, for blood count making. (AU)