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Study of potential modulators of the healing process on the proliferation of rabbits tenon's fibroblasts

Grant number: 12/00622-9
Support Opportunities:Regular Research Grants
Duration: June 01, 2012 - May 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Jayter Silva de Paula
Grantee:Jayter Silva de Paula
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Eduardo Melani Rocha


Currently, antifibrotic agents (such as 5-Fluoracil and mitomycin C) are used to inhibit the excessive scarring often observed in glaucoma surgeries (trabeculectomy - TREC). However, the use of these agents is associated with severe side effects most related to poor healing, and so, there is a need for the discovery of new, less aggressive, antifibrotic drugs.New compounds, such as phenolic derivatives and modulators of the renin-angiotensin pathway, have presented a potential antifibrotic action. The rosmarinic acid is a natural phenolic compound commonly found in species of Boraginaceae, with potential antifibrotic and anti-angiogenic actions. Similarly, the reduction of angiotensin II action, via AT1 receptor's inhibition by Losartan, was associated with regression of fibrosis in some tissues. Based on these findings, they could be used as potential adjuvant agents to TREC, in clinical practice, with fewer side effects. Previous studies in our laboratory have shown controversial antifibrotic effect of the rosmarinic acid in experimental models in vivo, warranting confirmation by other laboratory methods. Thus, the present project will study the effects of these drugs on the proliferation of rabbit Tenon's fibroblasts subjected to the proposed treatments, as well as the evaluation of gene expression and other factors related to tissue healing. A parallel perspective is the consolidation of our research line, involving the study of modulators of the inflammation/ healing processes in ocular tissues, with potential application in the clinical practice. Besides, it will enable the production and dissemination of scientific data through both presentations in scientific congresses and publication in refereed journals with international indexers. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAROLINA MARIA MÓDULO; LARISSA DOMENEGUETI FERREIRA; LILIAN ESLAINE COSTA MENDES DA SILVA; MARCO ANDREY CIPRIANI FRADE; PETER SOL REINACH; EDUARDO MELANI ROCHA; JAYTER SILVA PAULA. Efeito antifibrótico do Ácido Rosmarínico sobre os fibroblastos da Cápsula de Tenon estimulados com TGF-beta2: potencial terapêutico na cirurgia ocular. Arquivos Brasileiros de Oftalmologia, v. 83, n. 4, p. 305-311, . (12/00622-9)
MODULO, CAROLINA MARIA; FERREIRA, LARISSA DOMENEGUETI; COSTA MENDES DA SILVA, LILIAN ESLAINE; CIPRIANI FRADE, MARCO ANDREY; REINACH, PETER SOL; ROCHA, EDUARDO MELANI; PAULA, JAYTER SILVA. Anti-fibrotic effects of rosmarinic acid on Tenon's capsule fibroblasts stimulated with TGF-beta: therapeutic potential in ocular surgery. Arquivos Brasileiros de Oftalmologia, v. 83, n. 4, p. 7-pg., . (12/00622-9)

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