The inflammatory response involvement induced by Chlamydia pneumoniae and Mycoplasma pneumoniae in the acute myocardium infarction: possible mechanism by TLR

• Grant number: 06/04163-8
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2007
• End date: March 31, 2010
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Mario Hiroyuki Hirata
• Grantee: Mario Hiroyuki Hirata
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The infectious agents involvement in the physiopathology of arterioscleroses has been demonstrated in recent studies. However, the mechanism they participate is not clear. Recently, studies showed the involvement of Toll Like Receptors (TLR) through inflammatory response to microorganisms, leading the endotelial injury; therefore, the structural modifications of these receptors can be involved in the different inflammatory response and a higher susceptibility of infections. The aim of this study is to evaluate the involvement of the infectious agents in the inflammatory response through TLRs in acute myocardial infarction and to evaluate the possible mechanism between the Toll-like receptor 2 Arg753Gln, Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms and their respective activity, as well as the susceptibility to develop atherosclerotic plaque. This study will be carried out with patients that had acute myocardial infarction and individuals without evidence of cardiovascular illnesses. The TLR’s expression and polymorphism will be performed by real time PCR using peripheral blood cells. The plasma IgM and IgG anti-C. pneumoniae and anti-M. pneumoniae, the Protein C ultrasensible reactive (PCRus) and interleucina-6 (IL-6) concentrations will be determinate by immunochemistry methods. The result of this research will contribute to understand the involvement of the infectious agents and its relation with acute myocardial infarction. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA-NETO, LIDIO GONCALVES; CRESPO HIRATA, ROSARIO DOMINGUEZ; LUCHESSI, ANDRE DUCATI; SILBIGER, VIVIAN NOGUEIRA; STEPHANO, MARCO ANTONIO; SAMPAIO, MARCELO FERRAZ; ARMAGANIJAN, DIKRAN; HIRATA, MARIO HIROYUKI. CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, v. 36, n. 3, p. 332-340, OCT 2013. (06/04163-8)

LIMA-NETO, L. G.; HIRATA, R. D. C.; LUCHESSI, A. D.; SILBIGER, V. N.; CAVICHIOLI, D.; DOS SANTOS, E. S.; SOUSA, A. G. M.; SPROVIERI, S. R. S.; DE SOUSA-JUNIOR, E. B.; DOS SANTOS, F. C. P.; et al. CHLAMYDOPHILA PNEUMONIA AND INCREASED TLR4 GENE EXPRESSION IN LEUKOCYTES ARE ASSOCIATED WITH ACUTE MYOCARDIAL INFARCTION. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, v. 28, n. 3, p. 449-460, JUL-SEP 2014. (06/04163-8)