Pharmacological investigation of neurovascular mechanisms involved in the secretory phospholipases A2-induced acute pancreatitis

• Grant number: 07/00529-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2007
• End date: May 31, 2009
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Soraia Katia Pereira Costa
• Grantee: Soraia Katia Pereira Costa
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas, that is characterized by intense pancreatic necrosis and remote systemic effects such as the lung injury that is the main cause of death during acute pancreatitis. Evidences suggest that phospholipases A2 (PLA2) play an important role in the pathophysiology of acute pancreatitis. Experimental studies have shown that injection of PLA2 into the rat common bile duct induced acute pancreatitis (eg. increased microvascular permeability and leukocyte influx in both pancreas and lung) by a complex mechanism including neurovascular mediators such as substance P. This study was undertaken to investigate: 1) the direct influence of C-fibers and its neuropeptides (eg. substance P and the vasodilator calcitonin gene-related peptide [CGRP]) in both inflammation and pain signs observed in the PLA2-induced pancreatitis in rats. For this, several functional and biochemical approaches already established in our laboratpry will be used. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMARGO, ENILTON A.; ZANONI, CRISTIANE I.; TOYAMA, MARCOS H.; MUSCARA, MARCELO N.; DOCHERTY, REGINALD J.; COSTA, SORAIA K. P.. Abdominal hyperalgesia in secretory phospholipase A(2)-induced rat pancreatitis: Distinct roles of NK1 receptors. EUROPEAN JOURNAL OF PAIN, v. 15, n. 9, p. 900-906, OCT 2011. (07/00529-0)

CAMARGO, E. A.; SANTANA, D. G.; SILVA, C. I.; TEIXEIRA, S. A.; TOYAMA, M. H.; COTRIM, C.; LANDUCCI, E. C. T.; ANTUNES, E.; MUSCARA, M. N.; COSTA, S. K. P.. Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A(2). EUROPEAN JOURNAL OF PAIN, v. 18, n. 5, p. 691-700, MAY 2014. (07/00529-0)