LIGHT, MMP9, LTA, LGALS2, VCAM1, ICAM1, E-selectina and NFkB polymorphism can be associated with arterial coronary disease

• Grant number: 09/15864-5
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: January 31, 2013
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Mario Hiroyuki Hirata
• Grantee: Mario Hiroyuki Hirata
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Amanda Guerra de Moraes Rego Souza ; Dikran Armaganijan ; Marcelo Chiara Bertolami ; Marcelo Ferraz Sampaio ; Rosario Dominguez Crespo Hirata ; Simone Sorkin Arazi

Abstract

The aim of this research is a case-control study in a group of patients with acute infarction myocardial (AIM) and another group without coronary heart disease (CHD). In both groups will be studied some single nucleotide polymorphisms (SNPs) of genes LIGHT (rs344560 e rs2291668), MMP9 (rs17576), LT± (rs909253 e rs1041981), LGALS2 (rs7291467), VCAM1 (rs3176878), ICAM1 (rs281432), E-SELECTINA (rs5368) e NFºB (rs17032705) with genetics factors predisposing to the occurrence of early atherosclerosis. The gene expression and polymorphisms will be carried out by real time PCR of peripheral blood cells. This study might propose some pathways of inflammatory systems with be related with the LIGHT system and can be associated with early atherosclerosis because little has been described about its effects in vivo. (AU)