Study of genetic polymorphism associated with facila development in children with oral cleft in RN state

• Grant number: 08/05064-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2009
• End date: January 31, 2012
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Mario Hiroyuki Hirata
• Grantee: Mario Hiroyuki Hirata
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The oral cleft can be caused by ambiental and genetic factors. The aim of this study is to determine the effect of genetic polimorphism of the genes of MTFHR, MTR, MTRR, RFC1 and TR in the folate and homocistein level and search for new polimorfic or mutation in the genes MSX1, TGF-±, TGF-²3 and RARA and associate with oral cleft.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BEZERRA, J. F.; OLIVEIRA, G. H. M.; SOARES, C. D.; CARDOSO, M. L.; URURAHY, M. A. G.; NETO, F. P. F.; LIMA-NETO, L. G.; LUCHESSI, A. D.; SILBIGER, V. N.; FAJARDO, C. M.; et al. Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. ORAL DISEASES, v. 21, n. 3, p. 393-399, APR 2015. (08/05064-9)

CARDOSO, M. L.; BEZERRA, J. F.; OLIVEIRA, G. H. M.; SOARES, C. D.; OLIVEIRA, S. R.; DE SOUZA, K. S. C.; DA SILVA, H. P. V.; SILBIGER, V. N.; LUCHESSI, A. D.; FAJARDO, C. M.; et al. MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate. ORAL DISEASES, v. 19, n. 5, p. 507-512, JUL 2013. (08/05064-9)