Metalloproteinases 2 and 9 in the development of abdominal aneurysms: inhibition by doxycycline

• Grant number: 07/04212-1
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2008
• End date: December 31, 2009
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Simone Gusmão Ramos
• Grantee: Simone Gusmão Ramos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Abdominal aortic aneurysms (AAA) primarily affect elderly males with a prevalence of 5%. The natural history of aneurysms is to expand and eventually rupture, being responsible for 1,5% of the total mortality in males over 55 years of age. Despite the high frequency, much little it is known about their mechanisms of development and progression. This scarce knowledge must be, in part, to the lack of models animals comparable to this illness. We developed in our laboratory, one new model of AAA associating extrinsic stenosis and adventitial injury wall in aortas of rats. These two phenomena together contribute to development and progression of AAA during 30 days of experiment. There was adventitial inflammatory infiltrate followed for intense elastolytic activity and replacement of the arterial wall for abundant mesenchymal proliferation, predominantly smooth muscular cells (SMCs) embedded in extracellular matrix. The arterial dilatation is restricted to the remodeled area. Without the rheologic alterations promoted in this model, the aneurisms are not developed. Matrix metalloproteinases (MMPs) are known to degrade extracellular matrix and be up-regulated in aneurismal disease. The aim of this study is to evaluate the participation of metalloproteinases 2 and 9 (MMPs 2 and 9) in the development e progression of AAA in this model. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATA, KARINA M.; TEFE-SILVA, CRISTIANE; FLORIANO, ELAINE M.; FERNANDES, CLEVERSON R.; RIZZI, ELEN; GERLACH, RAQUEL F.; MAZZUCA, MARC Q.; RAMOS, SIMONE G.. Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms. CARDIOVASCULAR PATHOLOGY, v. 24, n. 2, p. 110-120, MAR-APR 2015. (07/04212-1)