Morphometry of phrenic nerves in spontaneously hypertensive rats

• Grant number: 09/16748-9
• Support Opportunities: Regular Research Grants
• Duration: June 01, 2010 - May 31, 2012
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Valéria Paula Sassoli Fazan
• Grantee: Valéria Paula Sassoli Fazan
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The phrenic nerve of rats is the main nerve involved in the respiratory control because it is the only source of innervation for the diaphragm. Histological examination of the diaphragm have shown gender differences in fiber composition and morphometry, but gender differences on the phrenic nerve morphology and morphometry were not examined yet. Studies that investigated the interaction between hypertension, gender and respiratory control have mainly focused the sleep apnea syndrome, and male gender and hypertension were suggested as risks for human sleep apnea. Animal models have been useful to investigate the relationship between hypertension and abnormal control of breathing. However, a possible relationship between hypertension and abnormal ventilatory control was never examined before in the spontaneously hypertensive rat (SHR), an outstanding hypertensive model. Moreover, the literature lacks a thorough description of the phrenic nerve morphology and morphometry in this experimental model an in the normotensive controls, the Wistar-Kyoto (WKY) rats. A descriptive morphologic and morphometric study of the phrenic nerves in male and female SHR and WKY will be investigated. Strain and gender differences on phrenic nerve myelinated fiber morphometry will be described for the first time in this experimental model of hypertension, pointing to the need for thorough functional studies of this nerve on male and female SHR. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANADA, LUCIANA SAYURI; TAVARES, MARCELO RODRIGO; MAIA NEUBERN, MILENA CARDOSO; SALGADO, HELIO CESAR; SASSOLI FAZAN, VALERIA PAULA. Ratos Wistar podem ser utilizados como os controles normotensos dos ratos espontaneamente hipertensos (SHR) em investigações morfométricas de nervos periféricos?. Acta Cirurgica Brasileira, v. 26, n. 6, p. 514-520, NOV-DEC 2011. (09/16748-9, 09/50389-6, 10/12518-6)

OLIVEIRA, FABRICIO S.; NESSLER, RANDY A.; CASTANIA, JACI A.; SALGADO, HELIO C.; FAZAN, VALERIA P. S.. Ultrastructural and morphometric alterations in the aortic depressor nerve of rats due to long term experimental diabetes: Effects of insulin treatment. Brain Research, v. 1491, p. 197-203, JAN 23 2013. (10/12518-6, 09/50389-6, 09/16748-9)

SANADA, LUCIANA SAYURI; DA ROCHA KALIL, ANDREA LURDES; TAVARES, MARCELO RODRIGO; MAIA NEUBERN, MILENA CARDOSO; SALGADO, HELIO CESAR; SASSOLI FAZAN, VALERIA PAULA. Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). BMC NEUROSCIENCE, v. 13, MAR 2 2012. (10/12518-6, 09/50389-6, 09/16748-9)

SATO, KARINA LAURENTI; SANADA, LUCIANA SAYURI; FERREIRA, RENATA DA SILVA; DE BARROS OLIVETI DE MARCO, MARIA CAROLINA DEL BEM; CASTANIA, JACI AIRTON; SALGADO, HELIO CESAR; NESSLER, RANDY ALAN; SASSOLI FAZAN, VALERIA PAULA. Renal nerve ultrastructural alterations in short term and long term experimental diabetes. BMC NEUROSCIENCE, v. 15, JAN 5 2014. (10/12518-6, 09/50389-6, 09/16748-9)

SANADA, LUCIANA SAYURI; TAVARES, MARCELO RODRIGO; SATO, KARINA LAURENTI; FERREIRA, RENATA DA SILVA; MAIA NEUBERN, MILENA CARDOSO; CASTANIA, JACI AYRTON; SALGADO, HELIO CESAR; SASSOLI FAZAN, VALERIA PAULA. Association of chronic diabetes and hypertension in sural nerve morphometry: an experimental study. DIABETOLOGY & METABOLIC SYNDROME, v. 7, FEB 15 2015. (13/01111-0, 13/20549-7, 09/16748-9)