The expression of regulatory chemokines of natural killer and T-regularoy cells in patients with endometriosis

• Grant number: 10/00475-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Sérgio Podgaec
• Grantee: Sérgio Podgaec
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Endometriosis is a common gynecological disorder, affecting 5-15% of women in the reproductive period and up to 3-5% in post-menopausal. Some aspects of this disease remain the subject of research, highlighting the search for the etiology in order to better understand the development of endometriosis focus and than, to direct efforts to improve diagnosis and treatment. In the past few years, much has been studied about immunological factors in the pathogenesis of endometriosis and many anomalies were found. For some reason, still uncertain, the endometrial cells that enter the endometrial cavity would not be eliminated and thus allow that they implement and develop the disease. The balance between immunity and tolerance is important for maintaining immune homeostasis and many mechanisms used to maintain the immune response under control as the active suppression by regulatory cells and the NK cell activity. It is known that NK cells play an important role in the clearance of endometrial cells in the peritoneal cavity and that T-reg cells likely play an important role in regulating this disease. Thus, to evaluate the expression of chemokines regulating the activity of NK cells (CXCL9, CXCL10, CXCL11, CXCL12, and CX3CL1 XCL1) and T-reg (CCL17 and CCL21) in topic and ectopic endometrium of patients with endometriosis and compare them to the topic endometrium of women without endometriosis would be an important step to understand this disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELLELIS, PATRICK; BARBEIRO, DENISE FREDIANI; RIZZO, LUIZ VICENTE; BARACAT, EDMUND CHADA; ABRAO, MAURICIO SIMOES; PODGAEC, SERGIO. Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis. Fertility and Sterility, v. 99, n. 7, p. 1987-1993, JUN 2013. (10/00475-0)

GUEUVOGHLANIAN-SILVA, BARBARA YASMIN; BELLELIS, PATRICK; BARBEIRO, DENISE FREDIANI; HERNANDES, CAMILA; PODGAEC, SERGIO. Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 126, p. 32-38, APR 2018. (10/00475-0)