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Regulatory mechanisms of cold shock response and stationary phase survival in Caulobacter crescentus


As the bacterial population grows, cells face a progressive reduction of nutrient availability that brings the need to respond slowing the reproductive rate and resetting the metabolism to withstand a long starvation period. The physiological effects of low temperature are somewhat similar to those of nutrient starvation, in that there is a reduction of ribosome function. The sensing of environmental signals is crucial for the cell to reset its gene expression to face the new situation. Small proteins containing a Cold Shock Domain (CSP) are induced at low temperature and/or stationary phase, and act as RNA chaperones, facilitating translation under these conditions, and as gene regulators. The main goal of this project is to identify the environmental signals, signal transduction systems and regulatory mechanisms of these genes important for C. crescentus response to low temperature and stationary phase. (AU)

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