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Epidemiologic study of rabies virus in wild mammals from a release Area, North Coast of São Paulo State, Brazil

Grant number: 09/09235-5
Support Opportunities:Regular Research Grants
Duration: December 01, 2009 - May 31, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Silvana Regina Favoretto
Grantee:Silvana Regina Favoretto
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Rabies is a zoonotic viral disease which causes thousands of humans and animals deaths worldwide annually. Several species of wild animals, as bats and carnivores mammals, presents a great importance in rabies epidemiology. Rabies virus study in those animal species can provide improved strategies of prevention and control of the disease. The use of samples from wildlife animals from a Release Area named Acarau Farm, in Bertioga County, north coast from São Paulo State, Brazil, provides an excellent opportunity for the study of sylvatic rabies epidemiology in the area. The aim of the present study is the detection of antirabies antibodies with Rapid Fluorescent Focus Inhibition Test (RFFIT) technique in sera of animals from the release area. And the detection of rabies virus trough Mouse Inoculation Test (MIT), Fluorescent Antibody Test (FAT) and Reverse transcriptase Polymerase Chain Reaction (RT-PCR) central nervous system samples from animals found dead in the area. In case of positive samples, the isolates will be antigenic and genetically characterized. (AU)

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