Serum and peritoneal fluid concentrations of acute phase proteins during experimental endotoxemia in horses

• Grant number: 09/15683-0
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2010
• End date: December 31, 2011
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Juliana Regina Peiró
• Grantee: Juliana Regina Peiró
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

In comparison with other species, horses are more sensitive to the effects of parenterally administered lipopolysaccharide (LPS) and endotoxin has a pivotal role in the pathogenesis of a number of important equine diseases, including laminitis, septic shock, colitis, colic, peritonitis, pleuritis, metritis, pneumonia and intestinal ischemia due to volvulus or intestinal entrapment. Interestingly, the administration of lidocaine immediately after exposure to endotoxin inhibited the inflammatory response as well as hypotension and metabolic acidosis in rabbits and had a profound inhibitory effect on the hemodynamic and cytokine responses to endotoxemia, demonstrating the potential usefulness of lidocaine as an anti-inflammatory agent in endotoxemia. In addition, lidocaine possesses anti-inflammatory properties with few side-effects at concentrations used in clinical practice, and inhibits the release of lisossomal enzymes by neutrophils. The aim of this study is to evaluate the production of acute phase proteins in serum or in peritoneal fluid, during an experimental model of endotoxemia in horses. (AU)