Effectiveness and tolerance infiltration intraarticular corticosteroid according to dose

• Grant number: 10/51092-4
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2010
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jamil Natour
• Grantee: Jamil Natour
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The optimal dose of corticosteroid to be used in intraarticular injection is not well established. The objective of this study is to compare the effectiveness and tolerance in the medium term between small and large dose of triamcinolone hexacetonide (TH) used in joint intraarticular injection (IAI) of small, medium and large size joints of patients with rheumatoid arthritis (RA). Materials/Methods: A controlled, randomized, prospective, double-blind study will be realized in patients with RA, where they will be evaluated joints representing small, medium and large (MCF-metacarpophalangeal, wrist and knee respectively). They will be recruited 180 patients from the outpatient clinics of Rheumatology, UNIFESP. Patients will be randomized (Clapboard randomization) in two groups of 30 patients each (large and small dose of HT). Only one joint is injected by patient (IIA blindly) each time. Evaluation will be conducted by a blinded observer at five times: baseline (TO), one week (Ti), four (T4), eight (T8) and twelve (T12) weeks, with the following instruments: visual analogic scale (VAS) for pain, VAS for swollen, Goniometry, Modified Stanford health assessment questionnaire (HAQ), clinical disease activity index (CDAI), percentage of improvement, Likert Scale, dose of anti-inflammatory and corticosteroids used for joint pain studied, morning stiffness, VAS for pain at the time of HA, VAS worse after IAI, local side effects, clinical evaluation of the patient. The level of statistical significance is 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA, DANIELE FREITAS; NATOUR, JAMIL; MACHADO, NATALIA PEREIRA; FURTADO, RITA NELY VILAR. Effectiveness of Intra-Articular Injection in Wrist Joints According to Triamcinolone Hexacetonide Dose in Rheumatoid Arthritis A Randomized Controlled Double-Blind Study. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 94, n. 2, p. 131-138, FEB 2015. (10/51092-4)