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Use of intra-articular botulinum toxin type A versus corticosteroids: a clinical trial in osteoarthritis of knees

Grant number: 14/05900-2
Support Opportunities:Regular Research Grants
Duration: December 01, 2014 - November 30, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Rita Nely Vilar Furtado
Grantee:Rita Nely Vilar Furtado
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Jamil Natour


Osteoarthritis (OA) of the knee is a very common disease. However, there are few treatment options for these patients. Botulinum toxin (TBA) is an option for chronic pain. If we prove effectiveness of its use for intra-articular analgesia, TBA can be useful to treat these patients. Objective: Compare the effectiveness of the use of intra-articular corticosteroid versus TBA in the treatment of patients with knee OA. Methods: A prospective controlled randomized double-blind studied with three groups (n = 33 each group) of patients with symptomatic OA of the knees to receive intra-articular medication in a single moment will be undertaken. The three groups will be: TBA Group: patients who receive 100U of botulinum toxin, HT Group: patients who receive 40 mg of triamcinolone hexacetonide, and SS group: patients who receive 2ml of normal saline. Patients will be assessed by evaluators "blind" in 8 times during 96 weeks of follow-up with clinical assessment instruments (pain at rest and movement, joint swelling, goniometry, range of clinical improvement, quality of life questionnaire as SF36), functional (WOMAC questionnaire, 6-min walk test, Time up and go test), and ultrasound (quantitative and semi quantitative measure of synovial hypertrophy and semi quantitative Power Doppler). The following statistical tests will be used : Student's t test, Mann - Whitney, chi-square test and ANOVA for repeated measures. Will be considered as statistical significance the difference of 5 %. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDES, JAMILLE GODOY; NATOUR, JAMIL; NUNES-TAMASHIRO, JOSE CARLOS; TOFFOLO, SANDRA REGINA; ROSENFELD, ANDRE; VILAR FURTADO, RITA NELY. Comparison between intra-articular Botulinum toxin type A, corticosteroid, and saline in knee osteoarthritis: a randomized controlled trial. CLINICAL REHABILITATION, v. 33, n. 6, p. 1015-1026, . (14/05900-2)

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