Inflammatory and metabolic mediators in different forms of Chagas disease: correlation with autonomic disfunction

• Grant number: 09/16887-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2010
• End date: December 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fabio Fernandes
• Grantee: Fabio Fernandes
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The main mechanisms for Chagas cardiomyopathy is the involvement of the Autonomic Nervous System (ANS), the microvascular dysfunction and inflammatory disorders. However, some aspects of the pathophysiology of chronic chagasic cardiomyopathy (CCC) are still unknown. The CCC has specific characteristics such as cardiac denervation and neurohormonal abnormalities that differ from other heart diseases. The association between metabolic mediators, inflammatory cytokines and autonomic dysfunction in patients with Chagas disease is controversial. This different pathophysiology suggests that some metabolic parameters may be altered in Chagas disease. The aim of this study will be measure metabolic markers such as blood lipids, glucose, insulin, leptin and adiponectin and inflammatory markers like interleukin-6 and tumor necrosis factor. We will measure the intima-media thickness of carotid arteries for assessment of subclinical atherosclerosis. These markers will be correlated with measures of function of the ANS. We believe that the contribution of this study will be a better understanding of the association between metabolic and inflammatory markers with autonomic dysfunction in the pathophysiology of Chagas disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA-FERREIRA, JOAO MARCOS; MADY, CHARLES; IANNI, BARBARA MARIA; LOPES, HENO FERREIRA; ALVAREZ RAMIRES, FELIX JOSE; CURY SALEMI, VERA MARIA; GRUPI, CESAR JOSE; HACHUL, DENISE TESSARIOL; FERNANDES, FABIO. Dysregulation of Autonomic Nervous System in Chagas' Heart Disease Is Associated with Altered Adipocytokines Levels. PLoS One, v. 10, n. 7, JUL 6 2015. (09/16887-9)