Advanced search
Start date

Environmental exposure and cognitive decline in healthy elderly: influence of psychosocial stress and oxidative stress


Over the past decades, several authors have demonstrated an association between glucocorticoids and memory in healthy elderly. In parallel, recent evidences have revealed that exposure to environmental contaminants (EC) such as lead, polychlorinated biphenyls and organochlorides, and also the oxidative stress is associated with age-related memory impairment. Some EC could interfere in the regulation of sexual steroid hormones. However, little is known about the influence of the EC in the glucocorticoids (stress hormone) and in the oxidativo stress biomarkers. Hence, the main goal of this study is to investigate the relationship between stress response and EC exposure and their association with cognitive performance and oxidative stress biomarkers in healthy elderly. Thus, 122 elderly who have been living in São Paulo metropolitan area, without cognitive impairment or neurological/psychiatric disorders will be evaluated. Saliva samples will be collected to verify diurnal cortisol cycle and also the cortisol concentration face and acute psychosocial stressor (‘Trier Social Stress Test’ - TSST). Besides, blood samples will be collected in order to analyze EC concentrations and oxidative stress biomarkers. It has been hypothesized that the cognitive performance variability in the elderly could be partially explained by the influence of EC exposure which may alter the stress response affecting the cognitive performance. Moreover, it has been propose that one of the mechanisms involved in this association is related to the increased levels of oxidative stress biomarkers. The current study could contribute to the understanding of healthy cognitive aging process and to drive studies about cognitive impairment aging. Besides this, the analysis about the impact of EC on stress response could set a stage for more complex models about the role of EC in the stress related disorders development. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA-TALARICO, JULIANA NERY; ALVES, ANDREA REGIANI; DOZZI BRUCKI, SONIA MARIA; NITRINI, RICARDO; LUPIEN, SONIA J.; SUCHECKI, DEBORAH. Cortisol reactivity to a psychosocial stressor significantly increases the risk of developing Cognitive Impairment no Dementia five years later. PSYCHONEUROENDOCRINOLOGY, v. 115, MAY 2020. Web of Science Citations: 0.
SOUZA-TALARICO, JULIANA N.; SUCHECKI, DEBORAH; JUSTER, ROBERT-PAUL; PLUSQUELLEC, PIERRICH; BARBOSA JUNIOR, FERNANDO; BUNSCHEIT, VINICIUS; MARCOURALCIS, TANIA; DE MATOS, TATIANE MARTINS; LUPIEN, SONIA J. Lead exposure is related to hypercortisolemic profiles and allostatic load in Brazilian older adults. Environmental Research, v. 154, p. 261-268, APR 2017. Web of Science Citations: 5.
SOUZA-TALARICO, JULIANA NERY; MARCOURAKIS, TANIA; BARBOSA, JR., FERNANDO; MORAES BARROS, SILVIA BERLANGA; RIVELLI, DIOGO PINEDA; POMPEIA, SABINE; CARAMELLI, PAULO; PLUSQUELLEC, PIERRICH; LUPIEN, SONIA J.; CATUCCI, RAPHAEL FERNANDES; ALVES, ANDREA REGIANI; SUCHECKI, DEBORAH. Association between heavy metal exposure and poor working memory and possible mediation effect of antioxidant defenses during aging. Science of The Total Environment, v. 575, p. 750-757, JAN 1 2017. Web of Science Citations: 3.
JULIANA RUMY TSUCHIHASHI TAKEDA; TATIANE MARTINS MATOS; JULIANA NERY DE SOUZA-TALARICO. Cardiovascular risk factors and cognitive performance in aging. Dement. Neuropsychol., v. 11, n. 4, p. -, Dez. 2017.
SOUZA-TALARICO, JULIANA N.; PLUSQUELLEC, PIERRICH; LUPIEN, SONIA J.; FIOCCO, ALEXANDRA; SUCHECKI, DEBORAH. Cross-Country Differences in Basal and Stress-Induced Cortisol Secretion in Older Adults. PLoS One, v. 9, n. 8 AUG 25 2014. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: