Studies on the effects of the high intensity ultrasound irradiation on the aqueous suspensions of chitin and chitosan

• Grant number: 10/02526-1
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2010
• End date: November 30, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Sérgio Paulo Campana Filho
• Grantee: Sérgio Paulo Campana Filho
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated researchers: Érika Virginia Raphael de Almeida

Abstract

The aqueous suspensions of alpha- and beta-chitin and chitosan will be treated with high intensity ultrasound irradiation in different conditions concerning the treatment duration and temperature, the power and the amplitude of the ultrasound irradiation. The effects of the ultrasound treatment will be evaluated according to the processing parameters, the chitin polymorph (alpha or beta), the concentration of the aqueous suspension and the composition of the suspension medium (water or aqueous solutions of NaOH of different concentrations). After the ultrasound treatment, the aqueous suspensions of chitin and chitosan will be evaluated with respect to its stability, particle´s average diameter and dispersity by using a dispersion analyzer. When the ultrasound treatment will be applied to chitin suspended in aqueous NaOH, the production of chitosan and the corresponding yield of the conversion will also be evaluated. The samples of chitosan will be characterized with respect to the average degree of acetylation, average molecular weight and polydispersity, crystallinity, solubility and thermal stability. The factorial planning and the optimization by the surface response methodology will be employed to determine the better conditions of the ultrasound treatment aiming to: i)the formation of stable particle´s dispersions with controlled dimensions and dispersity; ii)the reproducible deacetylation of chitin to produce chitosan with the desirable characteristics; iii)the high yield preparation of extensively deacetylated chitosan possessing high molecular weight and low polydispersity. The kinetics of the ultrasound-assisted deacetylation of chitin will be studied in the best processing conditions concerning the power and amplitude of the ultrasound irradiation aiming to determine the activation energy of the reaction and to investigate its mechanism. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FACCHINATTO, WILLIAM MARCONDES; FIAMINGO, ANDERSON; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO PAULO. Characterization and physical-chemistry of methoxypoly (ethylene glycol)-g-chitosan. International Journal of Biological Macromolecules, v. 124, p. 828-837, MAR 1 2019. (16/20970-2, 17/20973-4, 10/02526-1, 16/09720-4)

DOS SANTOS, DANILO MARTINS; LEITE, ILAIALI SOUZA; BUKZEM, ANDREA DE LACERDA; DE OLIVEIRA SANTOS, RACHEL PASSOS; FROLLINI, ELISABETE; INADA, NATALIA MAYUMI; CAMPANA-FILHO, SERGIO PAULO. Nanostructured electrospun nonwovens of poly(epsilon-caprolactone)/quaternized chitosan for potential biomedical applications. Carbohydrate Polymers, v. 186, p. 110-121, APR 15 2018. (10/02526-1)

DOS SANTOS, DANILO MARTINS; BUKZEM, ANDREA DE LACERDA; CAMPANA-FILHO, SERGIO PAULO. Response surface methodology applied to the study of the microwave-assisted synthesis of quaternized chitosan. Carbohydrate Polymers, v. 138, p. 317-326, MAR 15 2016. (10/02526-1)

BUKZEM, ANDREA DE LACERDA; DOS SANTOS, DANILO MARTINS; LEITE, ILAIALI SOUZA; INADA, NATALIA MAYUMI; CAMPANA-FILHO, SERGIO PAULO. Tuning the properties of carboxymethylchitosan-based porous membranes for potential application as wound dressing. International Journal of Biological Macromolecules, v. 166, p. 459-470, JAN 1 2021. (10/02526-1, 13/07276-1, 17/20973-4)