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Sympathetic and blood pressure answers to physical and guided breathing exercises in hypertensive

Grant number: 10/11413-6
Support type:Regular Research Grants
Duration: October 01, 2010 - March 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Decio Mion Junior
Grantee:Decio Mion Junior
Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers: Bruna Oneda ; Crivaldo Gomes Cardoso Júnior ; Giovanio Vieira da Silva ; Josiane Lima de Gusmão ; Katia Coelho Ortega ; Silvana de Barros ; Tatiana Goveia de Araujo


Hypertension is a major risk factor for cardiovascular disease. For its control, non-drug treatments such as exercise, aerobic, relaxation exercises and the use of equipment developed to decrease the respiratory rate - RESPeRATE ®, has been widely recommended, for having demonstrated significant hypotensive effect, both in pressure measurements in the office and in the ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM). However, the mechanisms related to this change are still not clear. The purpose of this study is to evaluate the immediate sympathetic nervous system responses and the arterial pressure response after aerobic activities using guided breathing. Therefore, there will be 20 patients selected, each of whom suffers from either hypertension stage I or stage II, without target organ damage, or other diseases, and after 4 weeks using placebo. The volunteer will make 5 visits: 1ª - Starting the study, beginning of the placebo period and MRPA; 2ª - Medical evaluation; 3ª - Randomization analyses and ergometric test 4a - Experimental session and ABPM; 5a - return ABPM. In the experimental session, the volunteer who were divided into intervention and control groups will have cycling exercise. After this, the volunteer will be laid down on the stretcher and will have his blood pressure checked using a validated oscillometric device DIXTAL on his arms. The process will also register the patient's autonomic modulations and microneurography during guided respiration exercise using Resperate® or while listening walkman with calm songs. Will be done 15 minutes intervention, and after this period, the Resperate® or mp4 will be taken out and the registers will continue extracting information for 10 more minutes (recovery period). So the equipment will be removed, the MAP will install the volunteer will make a snack and can go. (AU)

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