Adrenocortical hormonal evaluation in dogs with natural infection by Ehrlichia canis

• Grant number: 10/11630-7
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2010
• End date: September 30, 2012
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Mirela Tinucci Costa
• Grantee: Mirela Tinucci Costa
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The ehrlichiosis is a worldwide spread disease and may conduct the animal to death both by hemathologic changes and resulting emaciation, lethargy and anorexia, which can be explained by the disease's catabolic aspect. Such condition related to the illness may have multi-factorial implication in order to harm the metabolism and the mammals adaptation to the environment, functions related to the adrenal glands. Studies related to the endocrinologic changes of ehrlichiosis are rare and none was developed aiming evaluating the changes on the elements truly related to the adrenal activity. This project has the goal of evaluating the alterations related to the adrenal glands in dogs naturally infected by Ehrlichia canis (n=20), presenting parasitologic diagnosis or positive serology and PCR for the parasite, admitted at the Veterinary Hospital of FCAV/UNESP campus of Jaboticabal, through dosing serum levels of cortisol before and after stimulation with adrenocorticotropic hormone (ACTH), acute phase proteins (C reactive protein and haptoglobine) and dehydroepiandrosterone sulfate (DHEA-S) also before and after the stimulation with ACTH. The identification of the occurrence of those aspects may be useful to comprehend the ethio-physiopathogeny of this severe canine disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RONDELLI, M. C. H.; MUNHOZ, T. D.; CATANDI, P. B.; FRESCHI, C. R.; PALACIOS JUNIOR, R. J. G.; MACHADO, R. Z.; TINUCCI-COSTA, M.. Serum DHEA-S increases in dogs naturally infected with Ehrlichia canis. Research in Veterinary Science, v. 100, p. 18-20, JUN 2015. (10/02676-3, 10/11630-7)