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Functional analysis, expression and mutation of homeobox gene (HOXB7) in pancreatic adenocarcinomas

Grant number: 10/01421-1
Support Opportunities:Regular Research Grants
Duration: October 01, 2010 - December 31, 2012
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ricardo Rodrigues Giorgi
Grantee:Ricardo Rodrigues Giorgi
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Estela Maria Novak ; Márcia Saldanha Kubrusly ; Thais Chile

Abstract

Homeobox genes are known as genes controlling development and morphogenesis, because they act at the top of the genetic hierarchy regulating key aspects of embryogenesis, cell differentiation and morphogenesis in a number of organisms. Currently, the role of these genes in development and tumor progression has been extensively studied. Several findings have confirmed the role of deregulated expression of some HOX family members in several tumors, however, in pancreatic tumors no study evaluated the effect of HOXB7 gene. In a preliminary analysis conducted by our group, we observed that the mRNA of the gene HOXB7 were hyper-expressed in a strain of human pancreatic carcinoma (MiaPaCa-2). This study aims to: (1) identify the pattern of expression of HOXB7 gene in pancreatic tumors and normal tissue (2) identify possible gene amplification in tumor tissues (3) track possible mutations that may be crucial for the gene disruption (4) Knock down the HOXB7 gene by RNAi in the lineage of human pancreatic adenocarcinoma cells and analyzing the impact of gene expression and cell proliferation (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHILE, THAIS; HENRIQUES ZANELLA FORTES, MARIA ANGELA; CARDILLO CORREA-GIANNELLA, MARIA LUCIA; BRENTANI, HELENA PAULA; MARIA, DURVANEI AUGUSTO; PUGA, RENATO DAVID; DE PAULA, VANESSA DE JESUS R.; KUBRUSLY, MARCIA SALDANHA; NOVAK, ESTELA MARIA; BACCHELLA, TELESFORO; et al. HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis. BMC CANCER, v. 13, . (10/01421-1)

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