Markers of the haemostatic system and their correlation with clinical and laboratorial parameters in women with polycystic ovarian syndrome

• Grant number: 10/11707-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2010
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Cristina Laguna Benetti Pinto
• Grantee: Cristina Laguna Benetti Pinto
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Maria Raquel Marques Furtado de Mendonça Louzeiro

Abstract

According to the Rotterdam criteria, 2003, the Polycystic Ovarian Syndrome (PCOS) is a disease characterized by oligomenorrhea or amenorrhea, hyperandrogenism (clinic and/or laboratorial) and by the observation of polycystic ovarian on ultrasound. Women with PCOS may present increased probability of coagulation disturbances. Besides comparing some markers of the haemostatic system in women with and without PCOS, the present study aims to identify any relation between such markers and clinical/laboratorial parameters in women with PCOS. The study will recruit 90 patients from the Centro de Atenção Integral à Saúde da Mulher, Universidade Estadual de Campinas, which fulfilled the inclusion and exclusion criteria. Amongst them, 45 were diagnosed with PCOS, and the remaining 45 present normal gonadal function. They will be paired to the group of women with PCOS according to their age (± 2 years) and according to the body mass index (BMI) in the same stratification group. The data will be compared between the group of women with PCOS and the one with normal gonadal function through the paired T-test of Student. The correlation between the markers of hemostasis and some clinical and laboratorial parameters of women with PCOS will be assessed by the Pearson's correlation index. The considered significance level will be 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARQUES FURTADO DE MENDONCA-LOUZEIRO, MARIA RAQUEL; ANNICHINO-BIZZACCHI, JOYCE MARIA; BENETTI-PINTO, CRISTINA LAGUNA. Android fat distribution affects some hemostatic parameters in women with polycystic ovary syndrome compared with healthy control subjects matched for age and body mass index. Fertility and Sterility, v. 104, n. 2, p. 467-473, AUG 2015. (10/11707-0)

MARQUES FURTADO DE MENDONCA-LOUZEIRO, MARIA RAQUEL; ANNICHINO-BIZZACCHI, JOYCE MARIA; MAGNA, LUIS ALBERTO; PICOLI QUAINO, SUSAN KELLY; BENETTI-PINTO, CRISTINA LAGUNA. Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index. Fertility and Sterility, v. 99, n. 6, p. 1786-1790, MAY 2013. (10/11707-0)