SPECT with [99mTc] ECD scans in patients with cronic tinnitus after acunpucture treatment

• Grant number: 10/14804-6
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2011
• End date: August 31, 2013
• Field of knowledge: Health Sciences - Speech Therapy
• Principal Investigator: Andrea Parolin Jackowski
• Grantee: Andrea Parolin Jackowski
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Ektor Tsuneo Onishi ; Ilza Rosa Batista ; Roberta Ribeiro de Almeida ; Rodrigo Affonseca Bressan ; Shih Ming Chi

Abstract

Tinnitus is a frequent sympton and it is linked to emotional disorders, whose treatment has still been a challenge. Acupuncture is a promissing proposal, but the studies proving its benefits towards tinnitus are few. Objective: Evaluate the changes of brain blood flow in patients with tinnitus and regular audiometry undergone to acupuncture treatment. Methods: Sixty patients with tinnitus and regular audiometry will be randomed to have fifteen acupuncture sessions, active or placebo, and will be undergone to SPECT with [99mTc]ECD scans before and after the acupuncture sessions. The clinical evaluation will be done by Tinnitus Handicap Inventory (THI), by Visual Analogical Scale (VAS), by Beck Depression Inventory and Hamilton Anxiety Scale. Twenty healthy controls will have the SPECT with [99mTc]ECD only once to standard the blood flow. Expected Results: (1) Blood flow increase in temporal lobe in patients with tinnitus when compared to control group. (2) Blood flow decrease in temporal lobe in the group that will have active acupuncture when compared to a placebo group. (3) Improvement of the disconfort caused by tinnitus, kept for six moths, in the THI and EVA scores in the group undergo to active acupuncture. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAUREANO, MAURA REGINA; ONISHI, EKTOR TSUNEO; BRESSAN, RODRIGO AFFONSECA; BRAGA NETO, PEDRO; VIEIRA CASTIGLIONI, MARIO LUIZ; BATISTA, ILZA ROSA; REIS, MARILIA ALVES; GARCIA, MICHELE VARGAS; DE ANDRADE, ADRIANA NEVES; SANCHEZ, MAURA LIGIA; et al. The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using Tc-99m-ECD SPECT. EUROPEAN RADIOLOGY, v. 26, n. 9, p. 3234-3242, SEP 2016. (10/14804-6)

LAUREANO, MAURA REGINA; ONISHI, EKTOR TSUNEO; BRESSAN, RODRIGO AFFONSECA; VIEIRA CASTIGLIONI, MARIO LUIZ; BATISTA, ILZA ROSA; REIS, MARILIA ALVES; GARCIA, MICHELE VARGAS; DE ANDRADE, ADRIANA NEVES; DE ALMEIDA, ROBERTA RIBEIRO; GARRIDO, GRISELDA J.; et al. Memory Networks in Tinnitus: A Functional Brain Image Study. PLoS One, v. 9, n. 2, FEB 6 2014. (10/14804-6)