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Physical, chemical, mechanical and biological properties evaluation of MTA and Portland cement associated with micro and nanoparticulate radiopacifiers


The Mineral Trioxide Aggregate (MTA) is composed of Portland cement (PC) and radiopacifiers. The aim of this study is to evaluate the association of CP on zirconium oxide (OZ) and niobium oxide (iNO) in micro and nanoparticle formulation of retrograde materials and root canal sealers. Sub-project 1: It will be evaluate the resistance to compression (n = 6), setting time (n = 6), pH and calcium release (n = 10), flow (n = 10), superficial area (n = 10) and radiopacity (n = 6) of different formulations: a) CP, 2) MTA Angelus, 3) CP +30% OZ microparticulate, 4) +30% OZ nanosized CP, 5) +30% CP iNO microparticulate, 6) CP +30% nanoparticulate iNO. Sub-project 2: It will be evaluate setting time, resistance to compression, flow, film thickness, radiopacity, solubility, pH and the release of Ca++ cements MTA Fillapex, Sealapex, AH Plus, and two formulations experimental cement-based MTA with different radiopacifiers (zirconium oxide and niobium oxide as micro and nano particulate). Sub-project 3: All materials based on MTA evaluated for physico-chemical and mechanical in this study will be assessed in cell culture for toxicity and potential bioactive, as a part of the protocol for its use in humans. The tests will be conducted initially in fibroblasts from mice lineage MPDL and rat osteosarcoma cells (line ROS 17/2.8). Data will be analyzed statistically by the test of ANOVA and Tukey test with significance level of 5%. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, GUILHERME F.; BOSSO, ROBERTA; FERINO, RAFAEL V.; TANOMARU-FILHO, MARIO; BERNARDI, MARIA I. B.; GUERREIRO-TANOMARU, JULIANE M.; CERRI, PAULO S. Microparticulated and nanoparticulated zirconium oxide added to calcium silicate cement: Evaluation of physicochemical and biological properties. Journal of Biomedical Materials Research Part A, v. 102, n. 12, p. 4336-4345, DEC 2014. Web of Science Citations: 19.
GUERREIRO TANOMARU, JULIANE MARIA; STORTO, INARA; DA SILVA, GUILHERME FERREIRA; BOSSO, ROBERTA; COSTA, BERNARDO CESAR; BASSO BERNARDI, MARIA INES; TANOMARU-FILHO, MARIO. Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide. DENTAL MATERIALS JOURNAL, v. 33, n. 4, p. 466-470, AUG 2014. Web of Science Citations: 9.
VIAPIANA, R.; FLUMIGNAN, D. L.; GUERREIRO-TANOMARU, J. M.; CAMILLERI, J.; TANOMARU-FILHO, M. Physicochemical and mechanical properties of zirconium oxide and niobium oxide modified Portland cement-based experimental endodontic sealers. International Endodontic Journal, v. 47, n. 5, p. 437-448, MAY 2014. Web of Science Citations: 28.
VIAPIANA, RAQUELI; GUERREIRO-TANOMARU, JULIANE MARIA; TANOMARU-FILHO, MARIO; CAMILLERI, JOSETTE. Investigation of the Effect of Sealer Use on the Heat Generated at the External Root Surface during Root Canal Obturation Using Warm Vertical Compaction Technique with System B Heat Source. JOURNAL OF ENDODONTICS, v. 40, n. 4, p. 555-561, APR 2014. Web of Science Citations: 13.
VIAPIANA, RAQUELI; GUERREIRO-TANOMARU, J.; TANOMARU-FILHO, M.; CAMILLERI, J. Interface of dentine to root canal sealers. Journal of Dentistry, v. 42, n. 3, p. 336-350, MAR 2014. Web of Science Citations: 6.
SALLES, LOISE PEDROSA; GOMES-CORNELIO, ANA LIVIA; GUIMARAES, FELIPE COUTINHO; HERRERA, BRUNO SCHNEIDER; BAO, SONIA NAIR; ROSSA-JUNIOR, CARLOS; GUERREIRO-TANOMARU, JULIANE MARIA; TANOMARU-FILHO, MARIO. Mineral Trioxide Aggregate-based Endodontic Sealer Stimulates Hydroxyapatite Nucleation in Human Osteoblast-like Cell Culture. JOURNAL OF ENDODONTICS, v. 38, n. 7, p. 971-976, JUL 2012. Web of Science Citations: 34.

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