Electrical stimulation and recording of the neural activity into the inferior colliculus during the haloperidol-induced catalepsy: a behavioral and electrophysiologic study

• Grant number: 11/01409-4
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2011
• End date: April 30, 2013
• Field of knowledge: Humanities - Psychology - Physiological Psychology
• Principal Investigator: Liana Melo-Thomas
• Grantee: Liana Melo-Thomas
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• City of the host institution: Santos

Abstract

The inferior colliculus (IC) is primarily involved in auditory information processing but also integrates sensory information of aversive nature. It has been shown that the activation of the neural substrates of aversion of the IC by excitatory amino acids (EAA) causes freezing, escape behavior and immobility. Recently we demonstrated that an other kind of immobility, the catalepsy, can be influenced by the glutamatergic neural substract into the IC as the microinjection of glutamatergic antagonists (AP7 or MK-801) into this structure attenuates the haloperidol-induced catalepsy and the microinjection of glutamatergic agonist (NMDA) potentiates this catalepsy. However, how the IC influences this catalepsy is unclear. In this study it will be used the deep brain stimulation (DBS) method to examine the influence of the IC on the catalepsy induced by haloperidol. Considering that the electrodes used in the DBS method is able to stimulate and also recording the neural activity, it will be investigated if the glutamatergic neural substrate into the IC is able to influence the neural activity into the striatum, thalamus and substantia nigra. (AU)

Scientific publications

(6)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MEDEIROS, P.; DE FREITAS, R. L.; SILVA, M. O.; COIMBRA, N. C.; MELO-THOMAS, L.. CB1 CANNABINOID RECEPTOR-MEDIATED ANANDAMIDE SIGNALING MECHANISMS OF THE INFERIOR COLLICULUS MODULATE THE HALOPERIDOL-INDUCED CATALEPSY. Neuroscience, v. 337, p. 17-26, NOV 19 2016. (14/11869-0, 11/01409-4, 12/25167-2, 13/12916-0)

DE ANDRADE, J. S.; CESPEDES, I. C.; ABRAO, R. O.; DOS SANTOS, T. B.; DINIZ, L.; BRITTO, L. R. G.; SPADARI-BRATFISCH, R. C.; ORTOLANI, D.; MELO-THOMAS, L.; DA SILVAA, R. C. B.; et al. Chronic unpredictable mild stress alters an anxiety-related defensive response, Fos immunoreactivity and hippocampal adult neurogenesis. Behavioural Brain Research, v. 250, p. 81-90, AUG 1 2013. (11/17471-0, 11/01409-4)

MEDEIROS, P.; VIANA, M. B.; BARBOSA-SILVA, R. C.; TONELLI, L. C.; MELO-THOMAS, L.. Glutamatergic neurotransmission in the inferior colliculus influences intrastriatal haloperidol-induced catalepsy. Behavioural Brain Research, v. 268, p. 8-13, JUL 15 2014. (09/01437-8, 11/01409-4, 10/14446-2)

MELO-THOMAS, LIANA; THOMAS, UWE. Deep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?. Behavioural Brain Research, v. 279, p. 1-8, FEB 15 2015. (11/01409-4)

ZANGRANDO, JULIA; CARVALHEIRA, RENATA; LABBATE, GIOVANNA; MEDEIROS, PRISCILA; LONGO, BEATRIZ MONTEIRO; MELO-THOMAS, LIANA; BARBOSA SILVA, REGINA CLAUDIA. Atypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in rats. Behavioural Brain Research, v. 257, p. 77-82, NOV 15 2013. (12/01062-7, 11/01409-4, 12/05021-3, 10/14446-2, 12/06275-9)

TOSTES, J. G.; MEDEIROS, P.; MELO-THOMAS, L.. MODULATION OF HALOPERIDOL-INDUCED CATALEPSY IN RATS BY GABAERGIC NEURAL SUBSTRATE IN THE INFERIOR COLLICULUS. Neuroscience, v. 255, p. 212-218, DEC 26 2013. (09/01437-8, 11/01409-4)