Development of a new class of anti-hypertensive

• Grant number: 99/08231-2
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: November 01, 2000
• End date: June 30, 2006
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Gilberto de Nucci
• Grantee: Gilberto de Nucci
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Company: Laboratórios Biosintética Ltda
• City: São Paulo

Abstract

The aim of this project is to develop a new class of medicines for the treatment of cardiovascular diseases. This new class of medicines are the aspirinates. Basically, this involves attaching a molecule of anti-hypertensive substances (for example atenolol and carvedilol) and a calcium antagonist (nimodipine) to an aspirin molecule, given that aspirin offers a significant therapeutic effect when administered daily in low doses. The immediate advantage would be that the patient, by taking just one pill, would be ingesting a substance in vivo which would release two important main agents in the treatment of his disease. (AU)