The Danio rerio model as a tool to understand the linking between developmental neurotoxicity of metal species and some neurodegenerative diseases

• Grant number: 11/11921-4
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2011
• End date: February 28, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Raúl Bonne Hernández
• Grantee: Raúl Bonne Hernández
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

Brazil is one of the main producers of manganese and aluminum, which are neurotoxic during the development and associates with some illnesses of the aging (Parkinson's, Alzheimer's and Amyotrophic Lateral Sclerosis), with elevated costs for public health. In Brazil the national prevalence of Alzheimer's can arrive until 63% of the total of cases of dementia and 4% of the population with age above of 50 years must suffer of Parkinson's in year 2030. At today, the explanations to the development of the above-mentioned illnesses and the neurotoxicity of these metals are unclear, where the chemical speciation and the potential interaction among metal species have been neglected reiteratively. Thus, this project intends to study the importance of aluminum and manganese speciation and its associations for its neurotoxicological mechanisms and its implication on some neurodegenerative diseases. This project will contribute for the clarification of the respective studies of environmental and neurotoxicological risk assessment of metals. This is will be a basic, applied and explicative research. (AU)