Renal function markers, vitamin D and functional capacity in elderly

• Grant number: 11/12753-8
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2011
• End date: March 31, 2014
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Maysa Seabra Cendoroglo
• Grantee: Maysa Seabra Cendoroglo
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Lara Miguel Quirino Araujo ; Marcelo Costa Batista ; Maria Aparecida Dalboni ; Marise Lazaretti Castro ; Miguel Cendoroglo Neto ; Ricardo de Castro Cintra Sesso

Abstract

Some factors can modify the aging process and cause functional dependence in physical and cognitive domains. The evaluation of the renal function is a challenge in oldest old people that have kidney aging and comorbidities. The kidney disease influences in the functional capacity for acting directly in the cognition and also for other ways including vitamin D. Vitamin D has also action in physical and cognitive capacity in elderly people but we don´t know if it´s associated with the kidney function and can be prevented. The aim of this study is to analyze the relationship of the markers of renal function and vitamin D with the functional capacity in oldest old. This project will be a transversal study. 200 aged elderly above of 80 years is going to be studied. Serum creatinine and cystatin C is going to be used to calculate the glomerular filtration rate. We also are going to measure 25-OH-Colecalciferol, FGF-23, PTH and calcium in the serum. The functional capacity is going to be evaluated with the mini-examination of the mental state (MMSE), clock test , verbal fluency, the interview of performance in the basic activities (AVD) and instruments of daily life (AIVD), the grip strength and the timed test of five repetitions of rising from a chair and sitting down. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARIANA ZUCCOLOTTO FORONI; MAYSA SEABRA CENDOROGLO; ALINE GRANJA COSTA; ROSANGELA VILLA MARIN-MIO; PATRICIA FERREIRA DO PRADO MOREIRA; SERGIO SETSUO MAEDA; JOHN P. BILEZIKIAN; MARISE LAZARETTI-CASTRO. FGF23 levels as a marker of physical performance and falls in community-dwelling very old individuals. ARCHIVES OF ENDOCRINOLOGY METABOLISM, 2022-06-03. (11/12753-8)

QUIRINO ARAUJO, LARA MIGUEL; DO PRADO MOREIRA, PATRICIA FERREIRA; ALMADA FILHO, CLINEU DE MELLO; DE ARAUJO, LUCIANO VIEIRA; PASSOS, MICHELLE TIVERON; KIRSZTAJN, GIANNA MASTROIANNI; NETO, MIGUEL CENDOROGLO; CINTRA SESSO, RICARDO CASTRO; CENDOROGLO, MAYSA SEABRA. Functional capacity, renal function and vitamin D in community-dwelling oldest old. INTERNATIONAL UROLOGY AND NEPHROLOGY, v. 51, n. 4, p. 713-721, APR 2019. (11/12753-8)

FORONI, MARIANA ZUCCOLOTTO; CENDOROGLO, MAYSA SEABRA; SAKANE, ELIANE NAOMI; MARIN-MIO, ROSANGELA VILLA; DO PRADO MOREIRA, PATRICIA FERREIRA; MAEDA, SERGIO SETSUO; LAZARETTI-CASTRO, MARISE. Serum 25 hydroxyvitamin D concentrations in individuals over 80 years old and their correlations with musculoskeletal and health parameters. ENDOCRINE, v. N/A, p. 12-pg., 2022-10-28. (11/12753-8)

DUARTE, G.; ARAUJO, L. Q.; DI TOMMASO, A.; MAGALHAES FILHO, F. M.; CENDOROGLO, M. S.. Oldest old thyroid: similarities or differences?. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, v. 64, p. 2-pg., 2016-05-01. (11/12753-8)

PONTES, T. E.; MOREIRA, P. F.; ARAUJO, L. M.; TOMMASO, A. D.; AFFONSO, P. M.; CENDOROGLO, M. S.. 25(OH) VitD and Life Style of Oldest Old. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, v. 64, p. 1-pg., 2016-05-01. (11/12753-8)

MARIANA ZUCCOLOTTO FORONI; MAYSA SEABRA CENDOROGLO; ALINE GRANJA COSTA; ROSANGELA VILLA MARIN-MIO; PATRICIA FERREIRA DO PRADO MOREIRA; SERGIO SETSUO MAEDA; JOHN P. BILEZIKIAN; MARISE LAZARETTI-CASTRO. FGF23 levels as a marker of physical performance and falls in community-dwelling very old individuals. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 66, n. 3, p. 333-344, 2022-06-03. (11/12753-8)

QUIRINO ARAUJO, LARA MIGUEL; DO PRADO MOREIRA, PATRICIA FERREIRA; ALMADA FILHO, CLINEU DE MELLO; DE ARAUJO, LUCIANO VIEIRA; COSTA, ALINE GRANJA; CINTRA SESSO, RICARDO DE CASTRO; BILEZIKIAN, JOHN P.; LAZARETTI-CASTRO, MARISE; CENDOROGLO, MAYSA SEABRA. Association between fibroblast growth factor 23 and functional capacity among independent elderly individuals. Einstein (São Paulo), v. 19, 2021. (11/12753-8)