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Impact of prior use of parenteral omega-3 fatty acids and glutamine isolated and combined under the systemic inflammatory response and mortality in experimental acute pancreatitis

Grant number: 11/02071-7
Support type:Regular Research Grants
Duration: November 01, 2011 - April 30, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Dan Linetzky Waitzberg
Grantee:Dan Linetzky Waitzberg
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Clinical practice is the parenteral infusion of glutamine and omega-3 (AG n-3) in critical patients and surgical methods for modulating the immune response, metabolic and inflammatory. However, there are no enough reports to indicate the safety of combined use of parenteral glutamine and omega-3 fatty acids in conditions of metabolic stress. In this sense our goal is to verify in an experimental model of acute pancreatitis in rats, the effect of the use of single and combined solution of glutamine and parenteral lipid emulsion on the systemic inflammatory response and mortality.Keywords: lipid emulsion, parenteral glutamine, systemic inflammatory response. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GARLA, PRISCILA; GARIB, RICARDO; TORRINHAS, RAQUEL S.; MACHADO, MARCEL C. C.; CALDER, PHILIP C.; WAITZBERG, DAN L. Effect of parenteral infusion of fish oil-based lipid emulsion on systemic inflammatory cytokines and lung eicosanoid levels in experimental acute pancreatitis. Clinical Nutrition, v. 36, n. 1, p. 302-308, FEB 2017. Web of Science Citations: 2.
GARIB, RICARDO; GARLA, PRISCILA; TORRINHAS, RAQUEL S.; MORETTI, ANA I. S.; MACHADO, MARCEL C. C.; WAITZBERG, DAN L. Effect of Previous High Glutamine Infusion on Inflammatory Mediators and Mortality in an Acute Pancreatitis Model. Mediators of Inflammation, 2016. Web of Science Citations: 2.

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