Placental transfer of antibodies in multiple pregnancies

• Grant number: 11/13587-4
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2012
• End date: December 31, 2013
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Maria de Lourdes Brizot
• Grantee: Maria de Lourdes Brizot
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Adolfo Wenjaw Liao

Abstract

This is a prospective study envolving multiple pregnancies delivering at Clínica Obstetrica do Hospital das Clínicas da Faculdade de Medicina da USP. The aim of the study is to evaluate and compared immunoglobulin concentrations in maternal serum and umbilical cord after birth. Expression of specific immunoglobulins receptors in the placenta will be examined. Antibodies for specific neonatal infections (IgA anti-Stretococcus, anti-LPS Klebsyella and Pseudomonas) will also be evaluated in the differents compartments (maternal and umbilical cord). The present study is based on the hypothesis that in multiple pregnancies, maternal to fetal transplacental antibodies passage is different from singleton pregnancies. This difference is mainly assigned to the concurrent development of two or more fetuses in the uterus, with distinct total placental mass from those of single pregnancies. These differences induce adaptative needs in the maternal body that may interfere in the dinamic placental antibody transfer during pregnancy. With the intention to reduce the perinatal morbidity and mortality rates related to infections complications in the first days of life, the knowledgement of the factors that interferes in the placental transfer of antibodies in twin pregnancies constitute an important element to adequate the clinical management of these pregnancies. The Hospital das Clínicas da Faculdade de Medicina da USP is a tertiary referral center for obstetrics and perinatal care with high number of multiple pregnancies cases. Therefore it is a propitious place to develop this study to investigate the formulated hypothesis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STACH, SONIA C. L.; BRIZOT, MARIA DE L.; LIAO, ADOLFO W.; FRANCISCO, ROSSANA P. V.; PALMEIRA, PATRICIA; CARNEIRO-SAMPAIO, MAGDA; ZUGAIB, MARCELO. Transplacental Total IgG Transfer in Twin Pregnancies. American Journal of Reproductive Immunology, v. 72, n. 6, p. 555-560, DEC 2014. (11/13587-4)

STACH, S. C. L.; BRIZOT, M. L.; LIAO, A. W.; PALMEIRA, P.; FRANCISCO, R. P. V.; CARNEIRO-SAMPAIO, M. M. S.; ZUGAIB, M.. Placental Transfer of IgG Antibodies Specific to Klebsiella and Pseudomonas LPS and to Group B Streptococcus in Twin Pregnancies. Scandinavian Journal of Immunology, v. 81, n. 2, p. 135-141, FEB 2015. (11/13587-4)