Evaluation of the immune resposnse in respiratory healthy calves during the second quarter life

• Grant number: 11/17606-3
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2011
• End date: April 30, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Alice Maria Melville Paiva Della Libera
• Grantee: Alice Maria Melville Paiva Della Libera
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Bruna Parapinski dos Santos ; Camila Freitas Batista ; Heloisa Godoi Bertagnon ; Maiara Garcia Blagitz

Abstract

The maturation of the immune system is a widely researched subject. In cattle, this topic have been studied, and are target of disagreements about when the immune system responds with maximum efficiency. Their immaturity is related to the susceptibility of the animals to disease, as bronchopneumonia, whose is the one of the main causes of economic losses in cattle. This disease being more common until the fifth month of age in calves, and it's cause higher mortality rates after the second month of life of the calves. Thus, the purpose of this study is evaluate the maturation of the innate immune of the respiratory system of calves between 90 and 120 days. Ten healthy Holstein calves will be evaluated during three months, in six experimental moments. Blood sample and bronchoalveolar lavage fluid, obtained by endoscopy, will be analyzed for phagocytosis and burst oxidative assay. Quantification of immunoglobulins, expression of CD14 protein and quantification of cytokines produced (INFgamma, IL4, IL10, IL12) will be analyzed too. Statistical analysis of the data obtained in the evaluation of all components of blood serum and bronchoalvelar wash, will be accomplished by comparing the averages, examinated by the Tukey test or Mann-Whitney and Kruskal-Wallis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERTAGNON, HELOISA G.; BATISTA, CAMILA F.; SANTOS, KAMILA R.; GOMES, RENATA C.; BELLINAZZI, JESSYCA B.; DELLA LIBERA, ALICE MARIA M. P.. Alveolar macrophage functions during the transition phase to active immunity in calves. JOURNAL OF ANIMAL SCIENCE, v. 96, n. 9, p. 3738-3747, SEP 2018. (11/17606-3)