Evaluation of the fetal and neonatal brains in cases of severe twin-twin transfusion syndrome treated with laser ablation of placental vessels

• Grant number: 11/18469-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Cleisson Fabio Andrioli Peralta
• Grantee: Cleisson Fabio Andrioli Peralta
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Severe twin-twin transfusion syndrome is associated with higher risks of fetal and neonatal brain damages. These alterations can result from prenatal hemodynamic and hematologic disturbances associated to the pathophysiology of the disease or to the death of one twin, from acute hemodynamic changes caused by the laser ablation of placental vessels or from prematurity. Objectives: To describe and compare the incidences of brain alterations in the fetus (detected by ultrasound and magnetic resonance imaging) and neonate (detected by transfontanel scan) in cases of severe twin-twin transfusion syndrome treated with laser ablation of placental vessels. Pacients e methods: Descriptive observational study of 119 patients with severe twin-twin transfusion syndrome who will be treated with laser ablation of placental vessels. The incidences of fetal and neonatal brain alterations will be compared using the Chi-square test. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NETO, ORLANDO GOMES; MARINS, MARCOS; BOTELHO, RAFAEL D.; NIVOLONI, RAFAELA C.; SAURA, GLAUCO E.; ARIAS, AMABILE VESSONI; BARINI, RICARDO; PERALTA, CLEISSON F. A.. Feasibility and reproducibility of diffusion-weighted magnetic resonance imaging of the fetal brain in twin-twin transfusion syndrome. PRENATAL DIAGNOSIS, v. 34, n. 12, p. 1182-1188, DEC 2014. (11/18469-0)