| Grant number: | 11/08278-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2012 |
| End date: | January 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Martino Martinelli Filho |
| Grantee: | Martino Martinelli Filho |
| Host Institution: | Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated researchers: | Anísio Alexandre Andrade Pedrosa ; Giselle de Lima Peixoto ; Luiz Antonio Machado Cesar ; Marcos Guilherme Martinelli Saccab ; Mariana Moreira Lensi ; Sérgio Freitas de Siqueira ; Silvana Angelina D'Orio Nishioka ; Thiago Ovanessian Hueb ; Whady Armindo Hueb |
Abstract
Coronary artery disease (CAD) can evolve with ventricular remodeling leading to heart failure syndrome and electrophysiological dysfunctions responsible for fatal arrhythmic events. It is estimated that between 65 and 85% of sudden cardiac death (SCD) occur in patients with CAD. The therapeutic options for CAD has also been questioned in relation to clinical and functional evolution. In order to evaluate CAD progression and development of heart failure, based on the therapeutic management of our institution, this study was planned. Objectives: 1. Evaluate the incidence of cardiovascular events in patients undergoing treatment for CAD and LVEF <35%. 2. To assess the weight of clinical and functional variables that determine the outcome in follow-up. Outcome variables: - Primary: death from any cause, arrhythmic mortality, heart failure (HF), pulmonary thromboembolism ; -Secondary: occurrence of ventricular arrhythmias (VT / VF), myocardial infarction, thromboembolic episodes and hospitalization for cardiovascular events. Methods: Prospective registry database with automatic risk classification of patients with CAD and LVEF <35%, treated and followed up at our institution. Expected results: Identification of a subgroup of higher risk for SCD that would justify primary prevention. - Identification of a subgroup of patients at risk for worsening HF with resynchronization therapy indication. (AU)
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