| Grant number: | 12/14500-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2013 |
| End date: | August 31, 2015 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Leonardo Antonio Mamede Zornoff |
| Grantee: | Leonardo Antonio Mamede Zornoff |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| City of the host institution: | Botucatu |
| Associated researchers: | Katashi Okoshi ; Marcos Ferreira Minicucci ; Paula Schmidt Azevedo Gaiolla ; Sergio Alberto Rupp de Paiva |
Abstract
Heart failure is responsible by great number of hospitalization around the world. The main causes of heart failure are myocardium ischemia and hypertension. Considering the ischemic alterations, myocardial infarction play a critical role. After myocardial infarction, can occur complex alterations of the ventricular geometry, involving both infarcted and non infarcted regions. In the last years, this process is studied as cardiac remodeling. Importantly, remodeling process is associated with poor outcome and development of cardiac dysfunction and heart failure. Therefore, strategies to attenuate the remodeling process are a priority. Zinc is a metal essential to enzymes activity such as angiotensin converting enzyme, superoxide dismutases, and mettaloproteinases. In addition, this metal plays a critical role in the membrane, DNA, RNA, and ribossomes structure. Recently, there are evidences that zinc concentration is decreased in heart failure. This reduction can induce oxidative stress, inflammation and metaloproteinas activation. However, the effects of zinc supplementation after myocardial infarction are unknown. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |