Dengue prevalence in blood donors and recipients in Brazil: index of transmission by transfusion and clinical outcomes of dengue infection in recipients

• Grant number: 11/18955-1
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2012
• End date: February 28, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ester Cerdeira Sabino
• Grantee: Ester Cerdeira Sabino
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Lea Campos de Oliveira

Abstract

The WHO estimates that 50 million new dengue virus (DENV) infections occur worldwide each year resulting in 25,000 to 50,000 deaths. Recently high rates of RNA +donors to DENV observed by our group during epidemics in São Paulo, Honduras and the American Red Cross (American Red Cross - ARC) in Puerto Rico. These studies about viremia in donors were followed up by first well-documented reports of dengue transmission by transfusion in Singapore, Hong Kong and Puerto Rico. Because of high levels of viremia in donations documented during epidemic periods, it is difficult to understand why there are so few descriptions about DENV transmission through blood transfusion. Experience with WNV transmission by blood transfusion, a similar flavovirus carried by arthropods, suggests that Dengue transfusion-transmitted can occur commonly, but low investigated due to lack of active surveillance. As discussed in a recent Arbovirus Workshop at NIH in 2009December, questions about the rate of transmission by blood components and clinical consequences of infection by transfusion are keys to guide U.S. and global policies to DENV screening of blood supplies. In this study we will first establish the contents of the serological DENV indicators in donors and recipients in the receptor population with high exposure at the 4 bloodcenters in Brazil of RED-III Brasil to understand the basic indices of infection in these communities and the impact of past transfusions in the seroprevalence. We will set up the infrastructure needed for these kind of studies in Brazil. We will conduct a prospective study also focused to be developed in a dengue outbreak in the geographical area of capitation of one of the bloodcenters and will prepare a collection bound of donor-receivers, which will be tested by a DENV RNA test of high sensitivity to evaluate the transmission rate by transfusion of donations RNA + and the clinical outcome of recipients infection (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FARIA, NUNO R.; DA COSTA, ANTONIO CHARLYS; LOURENCO, JOSE; LOUREIRO, PAULA; LOPES, MARIA ESTHER; RIBEIRO, ROBERTO; ALENCAR, CECILIA SALETE; KRAEMER, MORITZ U. G.; VILLABONA-ARENAS, CHRISTIAN J.; WU, CHIEH-HSI; et al. Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil. SCIENTIFIC REPORTS, v. 7, NOV 9 2017. (16/01735-2, 11/18955-1, 17/00021-9)

SABINO, ESTER C.; LOUREIRO, PAULA; LOPES, MARIA ESTHER; CAPUANI, LIGIA; MCCLURE, CHRISTOPHER; CHOWDHURY, DHULY; DI-LORENZO-OLIVEIRA, CLAUDIA; OLIVEIRA, LEA C.; LINNEN, JEFFREY M.; LEE, TZONG-HAE; et al. Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil. Journal of Infectious Diseases, v. 213, n. 5, p. 694-702, MAR 1 2016. (11/18955-1)

BUSCH, MICHAEL P.; SABINO, ESTER C.; BRAMBILLA, DONALD; LOPES, MARIA ESTHER; CAPUANI, LIGIA; CHOWDHURY, DHULY; MCCLURE, CHRISTOPHER; LINNEN, JEFFREY M.; PRINCE, HARRY; SIMMONS, GRAHAM; et al. Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic. Journal of Infectious Diseases, v. 214, n. 1, p. 49-54, JUL 1 2016. (11/18955-1)