Abstract
Sepsis is a major public health problem, with an estimated 400,000 cases / year in Brazil which cause about 200,000 deaths and costs about $ 20 billion annually. With complex pathogenesis, morbidity / mortality depends on factors of the infecting microorganism, the host immune response and appropriate therapeutic interventions. In this project we plan to integrate basic and clinical research in sepsis, focusing on the pathogenesis and development of intervention strategies, education and dissemination of knowledge. To succeed in integrating basic and clinical, we will maintain the structure of the previous project, based on three lines of research: epidemiological and clinical, for multicenter assessment of epidemiological data and evaluating the impact of interventions; clinical and experimental-interface: to evaluate the cellular regulatory mechanisms during sepsis and study of pathogenic factors of microorganisms isolated from patients; experimental studies: for evaluation of pathophysiological mechanisms and strategies for therapeutic intervention in sepsis. These lines are structured in three integrated lines of action: 1-clinical and epidemiological, we have established a network of hospitals that prospectively follow patients with sepsis, with storage of clinical and epidemiological and biological sample collection; 2-clinical and experimental interface: biological samples from patients and controls obtained from the hospital network will be transported and processed in a central laboratory of immunology and microbiology; 3 - Experimental Research: where new hypotheses and potential therapeutic targets will be evaluated. (AU)
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