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Sepsis: integrating basic research and clinical research II

Grant number: 11/20401-4
Support type:Research Projects - Thematic Grants
Duration: April 01, 2012 - September 30, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Reinaldo Salomão
Grantee:Reinaldo Salomão
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Principal researchers:Ana Cristina Gales ; Ana Cristina Gales ; Ivan Hong Jun Koh ; Ivan Hong Jun Koh
Assoc. researchers:Eliezer Silva ; Flavia Ribeiro Machado ; Luciano Cesar Pontes de Azevedo ; Milena Karina Coló Brunialti ; Otelo Rigato Junior
Associated grant(s):16/12102-0 - 29th Annual Congress of the European Society of Intensive Care Medicine, AR.EXT
Associated scholarship(s):17/10523-1 - Study of the blood flow hemodynamics of the regional veins of the abdominal organs and its relation with macro and microcirculatory flows in sepsis, BP.IC
16/13855-2 - Evaluation of energy and oxidative metabolism in peripheral blood mononuclear cells (PBMC) from septic patients, BP.DR
15/21950-2 - Evaluation of CD39 and CD73 ectoenzymes expressed in lymphocytes, monocytes and neutrophils of septic patients, BP.IC
+ associated scholarships 15/17109-0 - Evaluation of genes expression involved in Nod-like receptor (NLR) activation in PBMCs from sequential samples of patients with sepsis secondary to real-time array PCR pneumonia, BP.IC
13/02265-1 - Characterization of the microcirculation dysfunction kinetics in sepsis, BP.PD
12/19738-7 - A computational method for the analysis of tissue and microvascular changes in organs with sepsis using the Sidestream Dark FieldImaging (SDF) imaging technique, BP.DR - associated scholarships

Abstract

Sepsis is a major public health problem, with an estimated 400,000 cases / year in Brazil which cause about 200,000 deaths and costs about $ 20 billion annually. With complex pathogenesis, morbidity / mortality depends on factors of the infecting microorganism, the host immune response and appropriate therapeutic interventions. In this project we plan to integrate basic and clinical research in sepsis, focusing on the pathogenesis and development of intervention strategies, education and dissemination of knowledge. To succeed in integrating basic and clinical, we will maintain the structure of the previous project, based on three lines of research: epidemiological and clinical, for multicenter assessment of epidemiological data and evaluating the impact of interventions; clinical and experimental-interface: to evaluate the cellular regulatory mechanisms during sepsis and study of pathogenic factors of microorganisms isolated from patients; experimental studies: for evaluation of pathophysiological mechanisms and strategies for therapeutic intervention in sepsis. These lines are structured in three integrated lines of action: 1-clinical and epidemiological, we have established a network of hospitals that prospectively follow patients with sepsis, with storage of clinical and epidemiological and biological sample collection; 2-clinical and experimental interface: biological samples from patients and controls obtained from the hospital network will be transported and processed in a central laboratory of immunology and microbiology; 3 - Experimental Research: where new hypotheses and potential therapeutic targets will be evaluated. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Com taxa de letalidade de 55,7%, sepse é a doença que mais mata em UTIs  
Sepsis kills most in ICUs, with 55.7% mortality rate 
La sepsis es la enfermedad que más mata en las UTIs de Brasil 
La reprogramación celular en pacientes con sepsis ayuda a entender el deterioro de la salud tras el alta 
Cell reprogramming in sepsis patients helps explain deterioration of health even after hospital discharge 
Articles published in other media outlets (39 total):
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News Medical (Austrália): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Health Medicine Network (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Technology Alpha: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
HealthMedicinentral: Sepsis can cause alterations in the functioning of defense cells that lead to death | HealthMedicinentral (12/May/2021)
Hekim.pro Doctor (Azerbaijão): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
SOHU.com (China): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Best Allergy Medicine HQ: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Eminetra Today (EUA): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Eminetra Today (EUA): Sepsis causes changes in the function of defense cells and can lead to death (12/May/2021)
The Uncover Reality (Índia): Cell Reprogramming in Sepsis Patients Helps Explain Deterioration of Health Even After hospital Discharge (Medicine) (12/May/2021)
Globe Health News: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
News O Time (Estados Unidos): Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
New.qq.com (China): 败血症会导致防御细胞功能的改变,从而导致死亡 - Sepse pode causar alterações na função das células de defesa, levando à morte (12/May/2021)
Detonic: Sensation discusses why clients that endure blood poisoning pass away quicker after medical facility discharge (12/May/2021)
Inter Reviewed: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Infinity CS News: Sepsis can cause alterations in the functioning of defense cells that lead to death (12/May/2021)
Jkwshk.tv (China): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Plexusmd.com: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (12/May/2021)
Medical Xpress (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Bioengineer (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Science Codex: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Scienmag Science Magazine (Reino Unido): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
InfoSurHoy (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
7thSpace: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Hekim.pro Doctor (Azerbaijão): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Health910: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Burada Biliyorum (Turquia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Freeschi: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Loire-net.tv (EUA): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
News O Time (Estados Unidos): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
LaptrinhX: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Biotech Asia News (Índia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
MediExpose (ìndia): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
4State News: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
The Health News Express: Phenomenon explains why sufferers who survive sepsis die sooner after hospital discharge (11/May/2021)
Патологоанатом Padolski (Ucrânia): Почему пациенты, пережившие сепсис, имеют все шансы умереть раньше, чем им было «уготовано» до этого (11/May/2021)
Vaccar.biz: Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
invesBrain (Canadá): Phenomenon explains why patients who survive sepsis die sooner after hospital discharge (11/May/2021)
Zephyrnet.com (Espanha): El fenómeno explica por qué los pacientes que sobreviven a la sepsis mueren antes del alta hospitalaria (11/May/2021)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SHARMA, NARENDRA KUMAR; FERREIRA, BIANCA LIMA; TASHIMA, ALEXANDRE KEIJI; COLO BRUNIALTI, MILENA KARINA; SOARES TORQUATO, RICARDO JOSE; BAFI, ANTONIO; ASSUNCAO, MURILLO; PONTES AZEVEDO, LUCIANO CESAR; SALOMAO, REINALDO. Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis. CLINICAL PROTEOMICS, v. 16, JUL 16 2019. Web of Science Citations: 2.
RAMON TEIXEIRA COSTA; ORLEI RIBEIRO DE ARAÚJO; MILENA KARINA COLÓ BRUNIALTI; MURILO SANTUCCI CESAR ASSUNÇÃO; LUCIANO CÉSAR PONTES AZEVEDO; FLÁVIO FREITAS; REINALDO SALOMÃO. T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality. Brazilian Journal of Infectious Diseases, v. 23, n. 2, p. 79-85, Mar. 2019. Web of Science Citations: 1.
FERREIRA DA MOTA, NADIJANE VALERIA; COLO BRUNIALTI, MILENA KARINA; SANTOS, SIDNEIA SOUSA; MACHADO, FLAVIA RIBEIRO; ASSUNCAO, MURILLO; PONTES AZEVEDO, LUCIANO CESAR; SALOMAO, REINALDO. IMMUNOPHENOTYPING OF MONOCYTES DURING HUMAN SEPSIS SHOWS IMPAIRMENT IN ANTIGEN PRESENTATION: A SHIFT TOWARD NONCLASSICAL DIFFERENTIATION AND UPREGULATION OF FC gamma RI-RECEPTOR. Shock, v. 50, n. 3, p. 293-300, SEP 2018. Web of Science Citations: 3.
SHARMA, NARENDRA KUMAR; TASHIMA, ALEXANDRE KEIJI; COLO BRUNIALTI, MILENA KARINA; FERREIRA, EDEN RAMALHO; SOARES TORQUATO, RICARDO JOSE; MORTARA, RENATO ARRUDA; MACHADO, FLAVIA RIBEIRO; ASSUNCAO, MURILLO; RIGATO, OTELO; SALOMAO, REINALDO. Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia. SCIENTIFIC REPORTS, v. 7, NOV 15 2017. Web of Science Citations: 4.
ESQUERDO, K. F.; SHARMA, N. K.; BRUNIALTI, M. K. C.; BAGGIO-ZAPPIA, G. L.; ASSUNCAO, M.; AZEVEDO, L. C. P.; BAFI, A. T.; SALOMAO, R. Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v. 189, n. 2, p. 232-240, AUG 2017. Web of Science Citations: 13.
ALVES-JANUZZI, AMANDA BARBA; COLO BRUNIALTI, MILENA KARINA; SALOMAO, REINALDO. CD163 and CD206 expression does not correlate with tolerance and cytokine production in LPS-tolerant human monocytes. CYTOMETRY PART B-CLINICAL CYTOMETRY, v. 92, n. 3, SI, p. 192-199, MAY 2017. Web of Science Citations: 5.
NUCCI, LAURA A.; SANTOS, SIDNEIA S.; BRUNIALTI, MILENA K. C.; SHARMA, NARENDRA KUMAR; MACHADO, FLAVIA R.; ASSUNCAO, MURILLO; DE AZEVEDO, LUCIANO C. P.; SALOMAO, REINALDO. Expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and mitochondrial oxidative phosphorylation in septic patients. PLoS One, v. 12, n. 2 FEB 9 2017. Web of Science Citations: 5.
SHARMA, NARENDRA KUMAR; SALOMAO, REINALDO. SEPSIS THROUGH THE EYES OF PROTEOMICS: THE PROGRESS IN THE LAST DECADE. Shock, v. 47, n. 1, 1, p. 17-25, JAN 2017. Web of Science Citations: 6.
DE ARAUJO, ORLEI RIBEIRO; SALOMAO, REINALDO; COLO BRUNIALTI, MILENA KARINA; BOURGUIGNON DA SILVA, DAFNE CARDOSO; SENERCHIA, ANDREZA ALMEIDA; DE MORAES COSTA CARLESSE, FABIANNE ALTRUDA; PETRILLI, ANTONIO SERGIO. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway. Mediators of Inflammation, 2017. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.