Influence of caloric restriction and resveratrol in the sirtuin system in women and men aged 55 to 65 years

• Grant number: 12/01051-5
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio de Padua Mansur
• Grantee: Antonio de Padua Mansur
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Celia Maria Cassaro Strunz

Abstract

Women have a natural protection that gives them greater longevity. One hypothesis most commonly used is the estrogen protection in the premenopausal period. However many studies of various forms of hormone replacement therapy proved ineffective in promoting additional protection for women. Thus, it is discussed other ways of protection associated with longevity in women. Of these, the sirtuína system was found in several animal studies to be associated with longevity. This system also showed, through the involvement of several metabolic pathways, an important protection against the process of atherosclerosis. But the activity of this system in humans is unknown and if it is more active in women than in men. The study's main objectives are to analyze this system in healthy 24 women and 24 men aged 55 to 65 years, and their influence on the main metabolic pathways related to longevity and the process of atherosclerosis. The research protocol includes analysis of the influence of sirtuin (SIRT1) in vascular reactivity, lipid profile, antioxidant capacity, markers of inflammation and homeostasis, before and after the interventions with caloric restriction or resveratrol administration. It is expected of this study mechanistic conclusions for longevity and possible clinical applications in the mechanism of atherosclerosis prevention. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONCALINHO, GUSTAVO HENRIQUE FERREIRA; KUWABARA, KAREN LIKA; FARIA, NATHALIA FERREIRA DE OLIVEIRA; GOES, MARISA FERNANDES DA SILVA; ROGGERIO, ALESSANDRA; AVAKIAN, SOLANGE DESIREE; STRUNZ, CELIA MARIA CASSARO; MANSUR, ANTONIO DE PADUA. Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol. NUTRIENTS, v. 15, n. 13, p. 16-pg., 2023-07-01. (12/01051-5)

ROGGERIO, ALESSANDRA; CASSARO STRUNZ, CELIA M.; PACANARO, ANA PAULA; LEAL, DALILA PINHEIRO; TAKADA, JULIO Y.; AVAKIAN, SOLANGE D.; MANSUR, ANTONIO DE PADUA. Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration. NUTRIENTS, v. 10, n. 7, JUL 2018. (12/01051-5)

GONCALINHO, GUSTAVO HENRIQUE FERREIRA; ROGGERIO, ALESSANDRA; GOES, MARISA FERNANDES DA SILVA; AVAKIAN, SOLANGE DESIREE; LEAL, DALILA PINHEIRO; STRUNZ, CELIA MARIA CASSARO; MANSUR, ANTONIO DE PADUA. Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial. Molecules, v. 26, n. 11, JUN 2021. (12/01051-5)