Comparison between acute exercise realized in sea level and hypoxia conditions on immune response

• Grant number: 11/10917-3
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2012
• End date: June 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Ronaldo Vagner Thomatieli dos Santos
• Grantee: Ronaldo Vagner Thomatieli dos Santos
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

In the last 20 years the number of studies to explain the relation between immunological system and physical exercise. It is described that the exercise may be an immunomodulator, stimulating or inhibiting the immune response. Already the hypoxia has been described as a powerful immunossupressor agent mainly by its capacity of increase the stress hormones concentration like the catecolaminas and the cortisol and also, diminish the concentration of glutamina. On the other hand, the effects of the exercise on immune function in hypoxia are poor understood. Studies suggest that to hipóxia can increase the effects of exercise upon the immune response and aggravate the imune response. It would be dependent of hypoxia level and time of exposition, however, methodological limitations show up contradictory results and do not permit definite conclusions. SIn this way this study has as objective the comparison between the effects of exercise to the sea level and in the hypoxia simulating an altitude of 4500m during 24 hours about the immune system. (AU)