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Effect of different intensities of exercise in hypoxia upon immunologic and inflammatory parameters

Grant number: 13/01324-4
Support type:Regular Research Grants
Duration: June 01, 2013 - May 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Effort
Principal Investigator:Ronaldo Vagner Thomatieli dos Santos
Grantee:Ronaldo Vagner Thomatieli dos Santos
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

Over the past 20 years has grown the number of studies attempting to explain the relationship between the immune system and exercise. Today it is known that exercise may be an immunomodulator, stimulating or inhibiting the immune response. IN the other hand hypoxia has been described as a potent immunosuppressive agent primarily for its ability to increase the concentration of stress hormones such as catecholamines and cortisol, and also decrease the concentration of glutamine, increase oxidative stress and inflammation. Moreover, the effects of exercise on inflammatory and immunological parameters in hypoxic conditions are poorly understood. Studies suggest that hypoxia can whom the effects of exercise on the immune response is exacerbated in a manner dependent on the level and time of exposure, however, methodological limitations result in contradictory results and do not allow definitive conclusions. Therefore, this study aims to evaluate the effects of different intensities of exercise in hypoxia simulating an altitude of 4500m on immune function, oxidative stress and inflammatory parameters. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACHADO, PAOLA; CARIS, ALINE; SANTOS, SAMILE; SILVA, EDGAR; OYAMA, LILA; TUFIK, SERGIO; SANTOS, RONALDO. Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia A controlled clinical trial. MEDICINE, v. 96, n. 4 JAN 2017. Web of Science Citations: 0.
CARIS, ALINE VENTICINQUE; DA SILVA, EDGAR TAVARES; DOS SANTOS, SAMILE AMORIM; LIRA, FABIO SANTOS; OYAMA, LILA MISSAE; TUFIK, SERGIO; THOMATIELI DOS SANTOS, RONALDO VAGNER. Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions. NUTRIENTS, v. 8, n. 11 NOV 2016. Web of Science Citations: 2.

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